Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial

PREDIMED-Plus Investigators

doi:10.1093/ije/dyy225

Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial

PREDIMED-Plus Investigators

Obesity Research

60 Citations (Scopus)

Abstract

The rationale for a new randomized trial (‘PREDIMEDPlus’) is to go beyond the previous PREDIMED trial, and to answer one of the most important questions in current medical practice: is an intentional body mass reduction through PA promotion and energy reduction, able to bring about in the long term a substantial reduction in hard cardiovascular clinical events? Our main hypothesis is that by addressing three lifestyle aspects (energy reduction with a high-quality
dietary pattern, recommendations on PA and motivational behaviour changes, based on providing persuasion and tools for solving problems, potentially derived from avoiding high calorie foods and sedentary lifestyles), an even stronger reduction in the risk of hard cardiovascular events will be attained, as compared with that observed with only a MedDiet.

Original language	English
Journal	International Journal of Epidemiology
Volume	48
Issue number	2
Pages (from-to)	387-388o
Number of pages	17
ISSN	0300-5771
DOIs	https://doi.org/10.1093/ije/dyy225
Publication status	Published - 1 Apr 2019

Access to Document

10.1093/ije/dyy225

dyy225.pdfFinal published version, 568 KB

Cite this

@article{c8fcd7a8ecb346d0ac2172201118d4cd,

title = "Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial",

abstract = "The rationale for a new randomized trial ({\textquoteleft}PREDIMEDPlus{\textquoteright}) is to go beyond the previous PREDIMED trial, and to answer one of the most important questions in current medical practice: is an intentional body mass reduction through PA promotion and energy reduction, able to bring about in the long term a substantial reduction in hard cardiovascular clinical events? Our main hypothesis is that by addressing three lifestyle aspects (energy reduction with a high-qualitydietary pattern, recommendations on PA and motivational behaviour changes, based on providing persuasion and tools for solving problems, potentially derived from avoiding high calorie foods and sedentary lifestyles), an even stronger reduction in the risk of hard cardiovascular events will be attained, as compared with that observed with only a MedDiet.",

author = "Mart{\'i}nez-Gonz{\'a}lez, {Miguel A} and Pilar Buil-Cosiales and Dolores Corella and Monica Bull{\'o} and Montserrat Fit{\'o} and Jes{\'u}s Vioque and Dora Romaguera and Mart{\'i}nez, {J Alfredo} and Julia W{\"a}rnberg and Jose L{\'o}pez-Miranda and Ram{\'o}n Estruch and Aurora Bueno-Cavanillas and Fernando Ar{\'o}s and Tur, {Josep A} and Francisco Tinahones and Lluis Serra-Majem and Vicente Mart{\'i}n and Jose Lapetra and Clotilde V{\'a}zquez and Xavier Pint{\'o} and Josep Vidal and Lidia Daimiel and Miguel Delgado-Rodr{\'i}guez and Pilar Mat{\'i}a and Emilio Ros and Fernando Fern{\'a}ndez-Aranda and Cristina Botella and Portillo, {Mar{\'i}a Puy} and Lamuela-Ravent{\'o}s, {Rosa M} and Ascensi{\'o}n Marcos and Guillermo S{\'a}ez and Enrique G{\'o}mez-Gracia and Miguel Ruiz-Canela and Estefania Toledo and Ismael Alvarez-Alvarez and Javier D{\'i}ez-Espino and Sorl{\'i}, {Jos{\'e} V} and Josep Basora and Olga Casta{\~n}er and Helmut Schr{\"o}der and Navarrete-Mu{\~n}oz, {Eva Mar{\'i}a} and Zulet, {Maria Angeles} and Antonio Garc{\'i}a-Rios and Jordi Salas-Salvad{\'o} and {PREDIMED-Plus Investigators} and Arne Astrup",

note = "Arne Astrup is a member of the Independent Data and Safety Monitoring Board of the PREDIMED-Plus Investigators.",

year = "2019",

month = apr,

day = "1",

doi = "10.1093/ije/dyy225",

language = "English",

volume = "48",

pages = "387--388o",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial

AU - Martínez-González, Miguel A

AU - Buil-Cosiales, Pilar

AU - Corella, Dolores

AU - Bulló, Monica

AU - Fitó, Montserrat

AU - Vioque, Jesús

AU - Romaguera, Dora

AU - Martínez, J Alfredo

AU - Wärnberg, Julia

AU - López-Miranda, Jose

AU - Estruch, Ramón

AU - Bueno-Cavanillas, Aurora

AU - Arós, Fernando

AU - Tur, Josep A

AU - Tinahones, Francisco

AU - Serra-Majem, Lluis

AU - Martín, Vicente

AU - Lapetra, Jose

AU - Vázquez, Clotilde

AU - Pintó, Xavier

AU - Vidal, Josep

AU - Daimiel, Lidia

AU - Delgado-Rodríguez, Miguel

AU - Matía, Pilar

AU - Ros, Emilio

AU - Fernández-Aranda, Fernando

AU - Botella, Cristina

AU - Portillo, María Puy

AU - Lamuela-Raventós, Rosa M

AU - Marcos, Ascensión

AU - Sáez, Guillermo

AU - Gómez-Gracia, Enrique

AU - Ruiz-Canela, Miguel

AU - Toledo, Estefania

AU - Alvarez-Alvarez, Ismael

AU - Díez-Espino, Javier

AU - Sorlí, José V

AU - Basora, Josep

AU - Castañer, Olga

AU - Schröder, Helmut

AU - Navarrete-Muñoz, Eva María

AU - Zulet, Maria Angeles

AU - García-Rios, Antonio

AU - Salas-Salvadó, Jordi

AU - PREDIMED-Plus Investigators

AU - Astrup, Arne

N1 - Arne Astrup is a member of the Independent Data and Safety Monitoring Board of the PREDIMED-Plus Investigators.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - The rationale for a new randomized trial (‘PREDIMEDPlus’) is to go beyond the previous PREDIMED trial, and to answer one of the most important questions in current medical practice: is an intentional body mass reduction through PA promotion and energy reduction, able to bring about in the long term a substantial reduction in hard cardiovascular clinical events? Our main hypothesis is that by addressing three lifestyle aspects (energy reduction with a high-qualitydietary pattern, recommendations on PA and motivational behaviour changes, based on providing persuasion and tools for solving problems, potentially derived from avoiding high calorie foods and sedentary lifestyles), an even stronger reduction in the risk of hard cardiovascular events will be attained, as compared with that observed with only a MedDiet.

AB - The rationale for a new randomized trial (‘PREDIMEDPlus’) is to go beyond the previous PREDIMED trial, and to answer one of the most important questions in current medical practice: is an intentional body mass reduction through PA promotion and energy reduction, able to bring about in the long term a substantial reduction in hard cardiovascular clinical events? Our main hypothesis is that by addressing three lifestyle aspects (energy reduction with a high-qualitydietary pattern, recommendations on PA and motivational behaviour changes, based on providing persuasion and tools for solving problems, potentially derived from avoiding high calorie foods and sedentary lifestyles), an even stronger reduction in the risk of hard cardiovascular events will be attained, as compared with that observed with only a MedDiet.

U2 - 10.1093/ije/dyy225

DO - 10.1093/ije/dyy225

M3 - Journal article

C2 - 30476123

SN - 0300-5771

VL - 48

SP - 387-388o

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 2

ER -

Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial

Abstract

Access to Document

Fingerprint

Cite this