TY - JOUR
T1 - Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial
AU - Martínez-González, Miguel A
AU - Buil-Cosiales, Pilar
AU - Corella, Dolores
AU - Bulló, Monica
AU - Fitó, Montserrat
AU - Vioque, Jesús
AU - Romaguera, Dora
AU - Martínez, J Alfredo
AU - Wärnberg, Julia
AU - López-Miranda, Jose
AU - Estruch, Ramón
AU - Bueno-Cavanillas, Aurora
AU - Arós, Fernando
AU - Tur, Josep A
AU - Tinahones, Francisco
AU - Serra-Majem, Lluis
AU - Martín, Vicente
AU - Lapetra, Jose
AU - Vázquez, Clotilde
AU - Pintó, Xavier
AU - Vidal, Josep
AU - Daimiel, Lidia
AU - Delgado-Rodríguez, Miguel
AU - Matía, Pilar
AU - Ros, Emilio
AU - Fernández-Aranda, Fernando
AU - Botella, Cristina
AU - Portillo, María Puy
AU - Lamuela-Raventós, Rosa M
AU - Marcos, Ascensión
AU - Sáez, Guillermo
AU - Gómez-Gracia, Enrique
AU - Ruiz-Canela, Miguel
AU - Toledo, Estefania
AU - Alvarez-Alvarez, Ismael
AU - Díez-Espino, Javier
AU - Sorlí, José V
AU - Basora, Josep
AU - Castañer, Olga
AU - Schröder, Helmut
AU - Navarrete-Muñoz, Eva María
AU - Zulet, Maria Angeles
AU - García-Rios, Antonio
AU - Salas-Salvadó, Jordi
AU - PREDIMED-Plus Investigators
AU - Astrup, Arne
N1 - Arne Astrup is a member of the Independent Data and Safety Monitoring Board of the PREDIMED-Plus Investigators.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - The rationale for a new randomized trial (‘PREDIMEDPlus’) is to go beyond the previous PREDIMED trial, and to answer one of the most important questions in current medical practice: is an intentional body mass reduction through PA promotion and energy reduction, able to bring about in the long term a substantial reduction in hard cardiovascular clinical events? Our main hypothesis is that by addressing three lifestyle aspects (energy reduction with a high-qualitydietary pattern, recommendations on PA and motivational behaviour changes, based on providing persuasion and tools for solving problems, potentially derived from avoiding high calorie foods and sedentary lifestyles), an even stronger reduction in the risk of hard cardiovascular events will be attained, as compared with that observed with only a MedDiet.
AB - The rationale for a new randomized trial (‘PREDIMEDPlus’) is to go beyond the previous PREDIMED trial, and to answer one of the most important questions in current medical practice: is an intentional body mass reduction through PA promotion and energy reduction, able to bring about in the long term a substantial reduction in hard cardiovascular clinical events? Our main hypothesis is that by addressing three lifestyle aspects (energy reduction with a high-qualitydietary pattern, recommendations on PA and motivational behaviour changes, based on providing persuasion and tools for solving problems, potentially derived from avoiding high calorie foods and sedentary lifestyles), an even stronger reduction in the risk of hard cardiovascular events will be attained, as compared with that observed with only a MedDiet.
U2 - 10.1093/ije/dyy225
DO - 10.1093/ije/dyy225
M3 - Journal article
C2 - 30476123
SN - 0300-5771
VL - 48
SP - 387-388o
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 2
ER -