Abstract
Aims Maternal diabetes may affect offspring cognitive function. The objective of the study was to evaluate cognitive function and potential predictors hereof in adult offspring of women with Type1 diabetes. Methods We conducted a follow-up study of adult offspring of women with Type1 diabetes (n=158) and a reference group from the background population (n=118). The main outcome measure was offspring cognitive function measured by global cognitive score, derived from Raven's Progressive Matrices and three verbal subtests from the Weschler Adult Intelligence Scale. Results Offspring of women with Type1 diabetes obtained lower global cognitive scores (94.8 vs. 100.0, P=0.004) than offspring from the background population. When adjusted for confounders, the groups no longer differed significantly (difference 0.4, 95%CI -3.3 to 4.). Positive predictors of cognitive function in offspring of women with diabetes were family social class, parental educational level, maternal diabetes duration, male gender and offspring age, whereas parity ≥1 and gestational age <34weeks were negative predictors. We found no association with maternal glycaemia during pregnancy or with neonatal hypoglycaemia. Conclusions Impaired cognitive function in adult offspring of women with Type1 diabetes compared with the background population apparently reflects differences with respect to well-known confounders. However, harmful effects of maternal hyperglycaemia may be mediated through delivery at <34weeks.
| Original language | English |
|---|---|
| Journal | Diabetic Medicine |
| Volume | 28 |
| Issue number | 7 |
| Pages (from-to) | 838-44 |
| Number of pages | 7 |
| ISSN | 0742-3071 |
| DOIs | |
| Publication status | Published - Jul 2011 |
Keywords
- Adolescent
- Adult
- Adult Children
- Analysis of Variance
- Cognition
- Diabetes Mellitus, Type 1
- Female
- Follow-Up Studies
- Humans
- Intelligence
- Pregnancy
- Pregnancy in Diabetics
- Young Adult
