Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers

Arjan Vissink; James B. Mitchell; Bruce J. Baum; Kirsten H. Limesand; Siri Beier Jensen; Philip C. Fox; Linda S. Elting; Johannes A. Langendijk; Robert P. Coppes; Mary E. Reyland

doi:10.1016/j.ijrobp.2010.06.052

Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers

Arjan Vissink, James B. Mitchell, Bruce J. Baum, Kirsten H. Limesand, Siri Beier Jensen, Philip C. Fox, Linda S. Elting, Johannes A. Langendijk, Robert P. Coppes, Mary E. Reyland

Department of Odontology

205 Citations (Scopus)

Abstract

The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy.

Original language	English
Journal	International Journal of Radiation Oncology, Biology, Physics
Volume	78
Issue number	4
Pages (from-to)	983-991
Number of pages	8
ISSN	0360-3016
DOIs	https://doi.org/10.1016/j.ijrobp.2010.06.052
Publication status	Published - 4 Nov 2010

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Vissink, A., Mitchell, J. B., Baum, B. J., Limesand, K. H., Jensen, S. B., Fox, P. C., Elting, L. S., Langendijk, J. A., Coppes, R. P., & Reyland, M. E. (2010). Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers. International Journal of Radiation Oncology, Biology, Physics, 78(4), 983-991. https://doi.org/10.1016/j.ijrobp.2010.06.052

Vissink, A, Mitchell, JB, Baum, BJ, Limesand, KH, Jensen, SB, Fox, PC, Elting, LS, Langendijk, JA, Coppes, RP & Reyland, ME 2010, 'Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers', International Journal of Radiation Oncology, Biology, Physics, vol. 78, no. 4, pp. 983-991. https://doi.org/10.1016/j.ijrobp.2010.06.052

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abstract = "The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy.",

author = "Arjan Vissink and Mitchell, {James B.} and Baum, {Bruce J.} and Limesand, {Kirsten H.} and Jensen, {Siri Beier} and Fox, {Philip C.} and Elting, {Linda S.} and Langendijk, {Johannes A.} and Coppes, {Robert P.} and Reyland, {Mary E.}",

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AU - Limesand, Kirsten H.

AU - Jensen, Siri Beier

AU - Fox, Philip C.

AU - Elting, Linda S.

AU - Langendijk, Johannes A.

AU - Coppes, Robert P.

AU - Reyland, Mary E.

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AB - The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy.

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DO - 10.1016/j.ijrobp.2010.06.052

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JF - International Journal of Radiation Oncology, Biology, Physics

IS - 4

ER -

Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers

Abstract

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