Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers

Arjan Vissink; James B. Mitchell; Bruce J. Baum; Kirsten H. Limesand; Siri Beier Jensen; Philip C. Fox; Linda S. Elting; Johannes A. Langendijk; Robert P. Coppes; Mary E. Reyland

doi:10.1016/j.ijrobp.2010.06.052

Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers

Arjan Vissink, James B. Mitchell, Bruce J. Baum, Kirsten H. Limesand, Siri Beier Jensen, Philip C. Fox, Linda S. Elting, Johannes A. Langendijk, Robert P. Coppes, Mary E. Reyland

Odontologisk Institut / Tandlægeskolen

205 Citationer (Scopus)

Abstract

The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy.

Originalsprog	Engelsk
Tidsskrift	International Journal of Radiation Oncology, Biology, Physics
Vol/bind	78
Udgave nummer	4
Sider (fra-til)	983-991
Antal sider	8
ISSN	0360-3016
DOI	https://doi.org/10.1016/j.ijrobp.2010.06.052
Status	Udgivet - 4 nov. 2010

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10.1016/j.ijrobp.2010.06.052

Citationsformater

Vissink, A., Mitchell, J. B., Baum, B. J., Limesand, K. H., Jensen, S. B., Fox, P. C., Elting, L. S., Langendijk, J. A., Coppes, R. P., & Reyland, M. E. (2010). Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers. International Journal of Radiation Oncology, Biology, Physics, 78(4), 983-991. https://doi.org/10.1016/j.ijrobp.2010.06.052

Vissink, A, Mitchell, JB, Baum, BJ, Limesand, KH, Jensen, SB, Fox, PC, Elting, LS, Langendijk, JA, Coppes, RP & Reyland, ME 2010, 'Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers', International Journal of Radiation Oncology, Biology, Physics, bind 78, nr. 4, s. 983-991. https://doi.org/10.1016/j.ijrobp.2010.06.052

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abstract = "The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy.",

author = "Arjan Vissink and Mitchell, {James B.} and Baum, {Bruce J.} and Limesand, {Kirsten H.} and Jensen, {Siri Beier} and Fox, {Philip C.} and Elting, {Linda S.} and Langendijk, {Johannes A.} and Coppes, {Robert P.} and Reyland, {Mary E.}",

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T2 - successes and barriers

AU - Vissink, Arjan

AU - Mitchell, James B.

AU - Baum, Bruce J.

AU - Limesand, Kirsten H.

AU - Jensen, Siri Beier

AU - Fox, Philip C.

AU - Elting, Linda S.

AU - Langendijk, Johannes A.

AU - Coppes, Robert P.

AU - Reyland, Mary E.

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AB - The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy.

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DO - 10.1016/j.ijrobp.2010.06.052

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Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers

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