Clinical association to FKBP5 rs1360780 in patients with depression

Henrik Dam; Jens O D Buch; Annelaura B. Nielsen; Pia Weikop; Thomas Werge; Martin B Jørgensen

doi:10.1097/YPG.0000000000000228

Clinical association to FKBP5 rs1360780 in patients with depression

Henrik Dam, Jens O D Buch, Annelaura B. Nielsen, Pia Weikop, Thomas Werge, Martin B Jørgensen

Abstract

The FKBP5 protein is of importance for the function of the glucocorticoid receptor. The purpose of the present study was to examine the possible association between the different genotypes of rs1360780 in the FKBP5 gene, and clinical symptoms in patients with unipolar depression. Seven hundred eighteen patients and 673 controls from the Danish Psychiatric Biobank were participated. No association was found between any genotype and diagnosis of unipolar depression. It was found that the group of depressed patients with the CC genotype showed significantly earlier start of treatment with medicine, had a significantly greater tendency to be treated with electroconvulsive therapy and showed a significantly higher frequency of family history of depression compared with the combined group of patients with the CT and TT genotypes. The only informations about controls were their sex and that they were recruited from the blood bank. The clinical data were not complete for all patients.

Original language	English
Journal	Psychiatric Genetics
Volume	29
Issue number	6
Pages (from-to)	220-225
Number of pages	6
ISSN	0955-8829
DOIs	https://doi.org/10.1097/YPG.0000000000000228
Publication status	Published - 1 Dec 2019

Access to Document

10.1097/YPG.0000000000000228

Cite this

@article{189c0e2a1463478e8c7f398a2b34b7ba,

title = "Clinical association to FKBP5 rs1360780 in patients with depression",

abstract = "The FKBP5 protein is of importance for the function of the glucocorticoid receptor. The purpose of the present study was to examine the possible association between the different genotypes of rs1360780 in the FKBP5 gene, and clinical symptoms in patients with unipolar depression. Seven hundred eighteen patients and 673 controls from the Danish Psychiatric Biobank were participated. No association was found between any genotype and diagnosis of unipolar depression. It was found that the group of depressed patients with the CC genotype showed significantly earlier start of treatment with medicine, had a significantly greater tendency to be treated with electroconvulsive therapy and showed a significantly higher frequency of family history of depression compared with the combined group of patients with the CT and TT genotypes. The only informations about controls were their sex and that they were recruited from the blood bank. The clinical data were not complete for all patients.",

author = "Henrik Dam and Buch, {Jens O D} and Nielsen, {Annelaura B.} and Pia Weikop and Thomas Werge and J{\o}rgensen, {Martin B}",

year = "2019",

month = dec,

day = "1",

doi = "10.1097/YPG.0000000000000228",

language = "English",

volume = "29",

pages = "220--225",

journal = "Psychiatric Genetics",

issn = "0955-8829",

publisher = "Lippincott Williams & Wilkins",

number = "6",

}

TY - JOUR

T1 - Clinical association to FKBP5 rs1360780 in patients with depression

AU - Dam, Henrik

AU - Buch, Jens O D

AU - Nielsen, Annelaura B.

AU - Weikop, Pia

AU - Werge, Thomas

AU - Jørgensen, Martin B

PY - 2019/12/1

Y1 - 2019/12/1

N2 - The FKBP5 protein is of importance for the function of the glucocorticoid receptor. The purpose of the present study was to examine the possible association between the different genotypes of rs1360780 in the FKBP5 gene, and clinical symptoms in patients with unipolar depression. Seven hundred eighteen patients and 673 controls from the Danish Psychiatric Biobank were participated. No association was found between any genotype and diagnosis of unipolar depression. It was found that the group of depressed patients with the CC genotype showed significantly earlier start of treatment with medicine, had a significantly greater tendency to be treated with electroconvulsive therapy and showed a significantly higher frequency of family history of depression compared with the combined group of patients with the CT and TT genotypes. The only informations about controls were their sex and that they were recruited from the blood bank. The clinical data were not complete for all patients.

AB - The FKBP5 protein is of importance for the function of the glucocorticoid receptor. The purpose of the present study was to examine the possible association between the different genotypes of rs1360780 in the FKBP5 gene, and clinical symptoms in patients with unipolar depression. Seven hundred eighteen patients and 673 controls from the Danish Psychiatric Biobank were participated. No association was found between any genotype and diagnosis of unipolar depression. It was found that the group of depressed patients with the CC genotype showed significantly earlier start of treatment with medicine, had a significantly greater tendency to be treated with electroconvulsive therapy and showed a significantly higher frequency of family history of depression compared with the combined group of patients with the CT and TT genotypes. The only informations about controls were their sex and that they were recruited from the blood bank. The clinical data were not complete for all patients.

U2 - 10.1097/YPG.0000000000000228

DO - 10.1097/YPG.0000000000000228

M3 - Journal article

C2 - 31219960

SN - 0955-8829

VL - 29

SP - 220

EP - 225

JO - Psychiatric Genetics

JF - Psychiatric Genetics

IS - 6

ER -

Clinical association to FKBP5 rs1360780 in patients with depression

Abstract

Access to Document

Fingerprint

Cite this