Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion

B Vozarova; C Weyer; K Hanson; P A Tataranni; C Bogardus; R E Pratley; Barbora de Courten

doi:10.1038/oby.2001.54

Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion

B Vozarova, C Weyer, K Hanson, P A Tataranni, C Bogardus, R E Pratley, Barbora de Courten

Torekov Group

458 Citations (Scopus)

Abstract

Plasma concentrations of interleukin-6 (IL-6), a proinflammatory cytokine produced and released in part by adipose tissue, are elevated in people with obesity and type 2 diabetes. Because recent studies suggest that markers of inflammation predict the development of type 2 diabetes, we examined whether circulating plasma IL-6 concentrations were related to direct measures of insulin resistance and insulin secretory dysfunction in Pima Indians, a population with high rates of obesity and type 2 diabetes.

Original language	English
Journal	Obesity Research
Volume	9
Issue number	7
Pages (from-to)	414-7
Number of pages	4
ISSN	1071-7323
DOIs	https://doi.org/10.1038/oby.2001.54
Publication status	Published - 1 Jul 2001

Keywords

Adipose Tissue
Adolescent
Adult
Arizona
Biological Markers
Body Composition
Diabetes Mellitus, Type 2
Enzyme-Linked Immunosorbent Assay
Fasting
Female
Glucose Clamp Technique
Glucose Tolerance Test
Humans
Indians, North American
Insulin
Insulin Resistance
Interleukin-6
Longitudinal Studies
Male
Obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/oby.2001.54

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title = "Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion",

abstract = "Plasma concentrations of interleukin-6 (IL-6), a proinflammatory cytokine produced and released in part by adipose tissue, are elevated in people with obesity and type 2 diabetes. Because recent studies suggest that markers of inflammation predict the development of type 2 diabetes, we examined whether circulating plasma IL-6 concentrations were related to direct measures of insulin resistance and insulin secretory dysfunction in Pima Indians, a population with high rates of obesity and type 2 diabetes.",

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author = "B Vozarova and C Weyer and K Hanson and Tataranni, {P A} and C Bogardus and Pratley, {R E} and {de Courten}, Barbora",

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T1 - Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion

AU - Vozarova, B

AU - Weyer, C

AU - Hanson, K

AU - Tataranni, P A

AU - Bogardus, C

AU - Pratley, R E

AU - de Courten, Barbora

PY - 2001/7/1

Y1 - 2001/7/1

N2 - Plasma concentrations of interleukin-6 (IL-6), a proinflammatory cytokine produced and released in part by adipose tissue, are elevated in people with obesity and type 2 diabetes. Because recent studies suggest that markers of inflammation predict the development of type 2 diabetes, we examined whether circulating plasma IL-6 concentrations were related to direct measures of insulin resistance and insulin secretory dysfunction in Pima Indians, a population with high rates of obesity and type 2 diabetes.

AB - Plasma concentrations of interleukin-6 (IL-6), a proinflammatory cytokine produced and released in part by adipose tissue, are elevated in people with obesity and type 2 diabetes. Because recent studies suggest that markers of inflammation predict the development of type 2 diabetes, we examined whether circulating plasma IL-6 concentrations were related to direct measures of insulin resistance and insulin secretory dysfunction in Pima Indians, a population with high rates of obesity and type 2 diabetes.

KW - Adipose Tissue

KW - Adolescent

KW - Adult

KW - Arizona

KW - Biological Markers

KW - Body Composition

KW - Diabetes Mellitus, Type 2

KW - Enzyme-Linked Immunosorbent Assay

KW - Fasting

KW - Female

KW - Glucose Clamp Technique

KW - Glucose Tolerance Test

KW - Humans

KW - Indians, North American

KW - Insulin

KW - Insulin Resistance

KW - Interleukin-6

KW - Longitudinal Studies

KW - Male

KW - Obesity

U2 - 10.1038/oby.2001.54

DO - 10.1038/oby.2001.54

M3 - Journal article

C2 - 11445664

SN - 1071-7323

VL - 9

SP - 414

EP - 417

JO - Obesity Research

JF - Obesity Research

IS - 7

ER -

Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion

Abstract

Keywords

UN SDGs

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