Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion

B Vozarova; C Weyer; K Hanson; P A Tataranni; C Bogardus; R E Pratley; Barbora de Courten

doi:10.1038/oby.2001.54

Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion

B Vozarova, C Weyer, K Hanson, P A Tataranni, C Bogardus, R E Pratley, Barbora de Courten

Torekov Group

458 Citationer (Scopus)

Abstract

Plasma concentrations of interleukin-6 (IL-6), a proinflammatory cytokine produced and released in part by adipose tissue, are elevated in people with obesity and type 2 diabetes. Because recent studies suggest that markers of inflammation predict the development of type 2 diabetes, we examined whether circulating plasma IL-6 concentrations were related to direct measures of insulin resistance and insulin secretory dysfunction in Pima Indians, a population with high rates of obesity and type 2 diabetes.

Originalsprog	Engelsk
Tidsskrift	Obesity Research
Vol/bind	9
Udgave nummer	7
Sider (fra-til)	414-7
Antal sider	4
ISSN	1071-7323
DOI	https://doi.org/10.1038/oby.2001.54
Status	Udgivet - 1 jul. 2001

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10.1038/oby.2001.54

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title = "Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion",

abstract = "Plasma concentrations of interleukin-6 (IL-6), a proinflammatory cytokine produced and released in part by adipose tissue, are elevated in people with obesity and type 2 diabetes. Because recent studies suggest that markers of inflammation predict the development of type 2 diabetes, we examined whether circulating plasma IL-6 concentrations were related to direct measures of insulin resistance and insulin secretory dysfunction in Pima Indians, a population with high rates of obesity and type 2 diabetes.",

keywords = "Adipose Tissue, Adolescent, Adult, Arizona, Biological Markers, Body Composition, Diabetes Mellitus, Type 2, Enzyme-Linked Immunosorbent Assay, Fasting, Female, Glucose Clamp Technique, Glucose Tolerance Test, Humans, Indians, North American, Insulin, Insulin Resistance, Interleukin-6, Longitudinal Studies, Male, Obesity",

author = "B Vozarova and C Weyer and K Hanson and Tataranni, {P A} and C Bogardus and Pratley, {R E} and {de Courten}, Barbora",

year = "2001",

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doi = "10.1038/oby.2001.54",

language = "English",

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journal = "Obesity Research",

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T1 - Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion

AU - Vozarova, B

AU - Weyer, C

AU - Hanson, K

AU - Tataranni, P A

AU - Bogardus, C

AU - Pratley, R E

AU - de Courten, Barbora

PY - 2001/7/1

Y1 - 2001/7/1

N2 - Plasma concentrations of interleukin-6 (IL-6), a proinflammatory cytokine produced and released in part by adipose tissue, are elevated in people with obesity and type 2 diabetes. Because recent studies suggest that markers of inflammation predict the development of type 2 diabetes, we examined whether circulating plasma IL-6 concentrations were related to direct measures of insulin resistance and insulin secretory dysfunction in Pima Indians, a population with high rates of obesity and type 2 diabetes.

AB - Plasma concentrations of interleukin-6 (IL-6), a proinflammatory cytokine produced and released in part by adipose tissue, are elevated in people with obesity and type 2 diabetes. Because recent studies suggest that markers of inflammation predict the development of type 2 diabetes, we examined whether circulating plasma IL-6 concentrations were related to direct measures of insulin resistance and insulin secretory dysfunction in Pima Indians, a population with high rates of obesity and type 2 diabetes.

KW - Adipose Tissue

KW - Adolescent

KW - Adult

KW - Arizona

KW - Biological Markers

KW - Body Composition

KW - Diabetes Mellitus, Type 2

KW - Enzyme-Linked Immunosorbent Assay

KW - Fasting

KW - Female

KW - Glucose Clamp Technique

KW - Glucose Tolerance Test

KW - Humans

KW - Indians, North American

KW - Insulin

KW - Insulin Resistance

KW - Interleukin-6

KW - Longitudinal Studies

KW - Male

KW - Obesity

U2 - 10.1038/oby.2001.54

DO - 10.1038/oby.2001.54

M3 - Journal article

C2 - 11445664

SN - 1071-7323

VL - 9

SP - 414

EP - 417

JO - Obesity Research

JF - Obesity Research

IS - 7

ER -

Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion

Abstract

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