Circulating cytokine concentrations in dogs with different degrees of myxomatous mitral valve disease

Nora Elisabeth Zois; Sophia Gry Moesgaard; Mads Kjelgaard-Hansen; Caroline Elisabeth Rasmussen; Bo Torkel Falk; Christine Fossing; Jens Häggström; Henrik Duelund Pedersen; Lisbeth Høier Olsen

doi:10.1016/j.tvjl.2011.05.009

Circulating cytokine concentrations in dogs with different degrees of myxomatous mitral valve disease

Nora Elisabeth Zois, Sophia Gry Moesgaard, Mads Kjelgaard-Hansen, Caroline Elisabeth Rasmussen, Bo Torkel Falk, Christine Fossing, Jens Häggström, Henrik Duelund Pedersen, Lisbeth Høier Olsen

Lifepharm

24 Citations (Scopus)

Abstract

Cytokines have been associated with the progression of congestive heart failure (CHF) in humans and may be implicated in the pathophysiology of myxomatous mitral valve disease (MMVD) in dogs. The aim of this study was to determine the serum concentrations of cytokines in dogs with MMVD. The study included 16 Cairn terriers with no or minimal mitral regurgitation (MR), 41 Cavalier King Charles Spaniels (CKCS) with different degrees of MR and 11 dogs of different breeds with CHF due to MMVD. Granulocyte-macrophage colony-stimulating factor, interferon-γ, interleukin (IL)-2, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, keratinocyte-derived chemokine, interferon-γ-induced protein and monocyte chemoattractant protein-1 (MCP-1) were measured using a canine-specific multiplex immunoassay.CHF dogs had significantly higher MCP-1 concentrations than dogs with no or minimal MR. Among the CKCS, IL-2 and IL-7 decreased with increasing left atrial size and IL-7 also decreased with increasing MR. IL-8 decreased with increasing left ventricular end-systolic internal dimensions. MCP-1 was increased in CHF dogs compared to healthy control dogs and IL-2, IL-7 and IL-8 decreased with increasing indices of disease severity. The results suggest a role for these cytokines in canine MMVD and CHF.

Original language	English
Journal	Veterinary Journal
Volume	192
Issue number	1
Pages (from-to)	106-111
Number of pages	6
ISSN	1090-0233
DOIs	https://doi.org/10.1016/j.tvjl.2011.05.009
Publication status	Published - Apr 2012

Keywords

Former LIFE faculty

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10.1016/j.tvjl.2011.05.009

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title = "Circulating cytokine concentrations in dogs with different degrees of myxomatous mitral valve disease",

abstract = "Cytokines have been associated with the progression of congestive heart failure (CHF) in humans and may be implicated in the pathophysiology of myxomatous mitral valve disease (MMVD) in dogs. The aim of this study was to determine the serum concentrations of cytokines in dogs with MMVD. The study included 16 Cairn terriers with no or minimal mitral regurgitation (MR), 41 Cavalier King Charles Spaniels (CKCS) with different degrees of MR and 11 dogs of different breeds with CHF due to MMVD. Granulocyte-macrophage colony-stimulating factor, interferon-γ, interleukin (IL)-2, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, keratinocyte-derived chemokine, interferon-γ-induced protein and monocyte chemoattractant protein-1 (MCP-1) were measured using a canine-specific multiplex immunoassay.CHF dogs had significantly higher MCP-1 concentrations than dogs with no or minimal MR. Among the CKCS, IL-2 and IL-7 decreased with increasing left atrial size and IL-7 also decreased with increasing MR. IL-8 decreased with increasing left ventricular end-systolic internal dimensions. MCP-1 was increased in CHF dogs compared to healthy control dogs and IL-2, IL-7 and IL-8 decreased with increasing indices of disease severity. The results suggest a role for these cytokines in canine MMVD and CHF.",

keywords = "Former LIFE faculty, Myxomatus mital valv disease, Canine, Cytokines, Interlukins, Monocyte chemoattractant protein-1",

author = "Zois, {Nora Elisabeth} and Moesgaard, {Sophia Gry} and Mads Kjelgaard-Hansen and Rasmussen, {Caroline Elisabeth} and Falk, {Bo Torkel} and Christine Fossing and Jens H{\"a}ggstr{\"o}m and Pedersen, {Henrik Duelund} and Olsen, {Lisbeth H{\o}ier}",

year = "2012",

month = apr,

doi = "10.1016/j.tvjl.2011.05.009",

language = "English",

volume = "192",

pages = "106--111",

journal = "The Veterinary Journal",

issn = "1090-0233",

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T1 - Circulating cytokine concentrations in dogs with different degrees of myxomatous mitral valve disease

AU - Zois, Nora Elisabeth

AU - Moesgaard, Sophia Gry

AU - Kjelgaard-Hansen, Mads

AU - Rasmussen, Caroline Elisabeth

AU - Falk, Bo Torkel

AU - Fossing, Christine

AU - Häggström, Jens

AU - Pedersen, Henrik Duelund

AU - Olsen, Lisbeth Høier

PY - 2012/4

Y1 - 2012/4

N2 - Cytokines have been associated with the progression of congestive heart failure (CHF) in humans and may be implicated in the pathophysiology of myxomatous mitral valve disease (MMVD) in dogs. The aim of this study was to determine the serum concentrations of cytokines in dogs with MMVD. The study included 16 Cairn terriers with no or minimal mitral regurgitation (MR), 41 Cavalier King Charles Spaniels (CKCS) with different degrees of MR and 11 dogs of different breeds with CHF due to MMVD. Granulocyte-macrophage colony-stimulating factor, interferon-γ, interleukin (IL)-2, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, keratinocyte-derived chemokine, interferon-γ-induced protein and monocyte chemoattractant protein-1 (MCP-1) were measured using a canine-specific multiplex immunoassay.CHF dogs had significantly higher MCP-1 concentrations than dogs with no or minimal MR. Among the CKCS, IL-2 and IL-7 decreased with increasing left atrial size and IL-7 also decreased with increasing MR. IL-8 decreased with increasing left ventricular end-systolic internal dimensions. MCP-1 was increased in CHF dogs compared to healthy control dogs and IL-2, IL-7 and IL-8 decreased with increasing indices of disease severity. The results suggest a role for these cytokines in canine MMVD and CHF.

AB - Cytokines have been associated with the progression of congestive heart failure (CHF) in humans and may be implicated in the pathophysiology of myxomatous mitral valve disease (MMVD) in dogs. The aim of this study was to determine the serum concentrations of cytokines in dogs with MMVD. The study included 16 Cairn terriers with no or minimal mitral regurgitation (MR), 41 Cavalier King Charles Spaniels (CKCS) with different degrees of MR and 11 dogs of different breeds with CHF due to MMVD. Granulocyte-macrophage colony-stimulating factor, interferon-γ, interleukin (IL)-2, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, keratinocyte-derived chemokine, interferon-γ-induced protein and monocyte chemoattractant protein-1 (MCP-1) were measured using a canine-specific multiplex immunoassay.CHF dogs had significantly higher MCP-1 concentrations than dogs with no or minimal MR. Among the CKCS, IL-2 and IL-7 decreased with increasing left atrial size and IL-7 also decreased with increasing MR. IL-8 decreased with increasing left ventricular end-systolic internal dimensions. MCP-1 was increased in CHF dogs compared to healthy control dogs and IL-2, IL-7 and IL-8 decreased with increasing indices of disease severity. The results suggest a role for these cytokines in canine MMVD and CHF.

KW - Former LIFE faculty

KW - Myxomatus mital valv disease

KW - Canine

KW - Cytokines

KW - Interlukins

KW - Monocyte chemoattractant protein-1

U2 - 10.1016/j.tvjl.2011.05.009

DO - 10.1016/j.tvjl.2011.05.009

M3 - Journal article

SN - 1090-0233

VL - 192

SP - 106

EP - 111

JO - The Veterinary Journal

JF - The Veterinary Journal

IS - 1

ER -

Circulating cytokine concentrations in dogs with different degrees of myxomatous mitral valve disease

Abstract

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