Circulating cytokine concentrations in dogs with different degrees of myxomatous mitral valve disease

TY - JOUR

T1 - Circulating cytokine concentrations in dogs with different degrees of myxomatous mitral valve disease

AU - Zois, Nora Elisabeth

AU - Moesgaard, Sophia Gry

AU - Kjelgaard-Hansen, Mads

AU - Rasmussen, Caroline Elisabeth

AU - Falk, Bo Torkel

AU - Fossing, Christine

AU - Häggström, Jens

AU - Pedersen, Henrik Duelund

AU - Olsen, Lisbeth Høier

PY - 2012/4

Y1 - 2012/4

N2 - Cytokines have been associated with the progression of congestive heart failure (CHF) in humans and may be implicated in the pathophysiology of myxomatous mitral valve disease (MMVD) in dogs. The aim of this study was to determine the serum concentrations of cytokines in dogs with MMVD. The study included 16 Cairn terriers with no or minimal mitral regurgitation (MR), 41 Cavalier King Charles Spaniels (CKCS) with different degrees of MR and 11 dogs of different breeds with CHF due to MMVD. Granulocyte-macrophage colony-stimulating factor, interferon-γ, interleukin (IL)-2, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, keratinocyte-derived chemokine, interferon-γ-induced protein and monocyte chemoattractant protein-1 (MCP-1) were measured using a canine-specific multiplex immunoassay.CHF dogs had significantly higher MCP-1 concentrations than dogs with no or minimal MR. Among the CKCS, IL-2 and IL-7 decreased with increasing left atrial size and IL-7 also decreased with increasing MR. IL-8 decreased with increasing left ventricular end-systolic internal dimensions. MCP-1 was increased in CHF dogs compared to healthy control dogs and IL-2, IL-7 and IL-8 decreased with increasing indices of disease severity. The results suggest a role for these cytokines in canine MMVD and CHF.

AB - Cytokines have been associated with the progression of congestive heart failure (CHF) in humans and may be implicated in the pathophysiology of myxomatous mitral valve disease (MMVD) in dogs. The aim of this study was to determine the serum concentrations of cytokines in dogs with MMVD. The study included 16 Cairn terriers with no or minimal mitral regurgitation (MR), 41 Cavalier King Charles Spaniels (CKCS) with different degrees of MR and 11 dogs of different breeds with CHF due to MMVD. Granulocyte-macrophage colony-stimulating factor, interferon-γ, interleukin (IL)-2, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, keratinocyte-derived chemokine, interferon-γ-induced protein and monocyte chemoattractant protein-1 (MCP-1) were measured using a canine-specific multiplex immunoassay.CHF dogs had significantly higher MCP-1 concentrations than dogs with no or minimal MR. Among the CKCS, IL-2 and IL-7 decreased with increasing left atrial size and IL-7 also decreased with increasing MR. IL-8 decreased with increasing left ventricular end-systolic internal dimensions. MCP-1 was increased in CHF dogs compared to healthy control dogs and IL-2, IL-7 and IL-8 decreased with increasing indices of disease severity. The results suggest a role for these cytokines in canine MMVD and CHF.

KW - Former LIFE faculty

KW - Myxomatus mital valv disease

KW - Canine

KW - Cytokines

KW - Interlukins

KW - Monocyte chemoattractant protein-1

U2 - 10.1016/j.tvjl.2011.05.009

DO - 10.1016/j.tvjl.2011.05.009

M3 - Journal article

SN - 1090-0233

VL - 192

SP - 106

EP - 111

JO - The Veterinary Journal

JF - The Veterinary Journal

IS - 1

ER -