Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test

Jesper Andreasen T.; Elsebet O Nielsen; John P Redrobe

doi:10.1007/s00213-009-1560-1

Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test

Jesper Andreasen T., Elsebet O Nielsen, John P Redrobe

Department of Clinical Medicine

16 Citations (Scopus)

Abstract

Smoking rates among depressed individuals is higher than among healthy subjects, and nicotine alleviates depressive symptoms. Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. In mice, acute nicotine administration enhances the activity of antidepressants in the mouse forced swim (mFST) and tail suspension tests. Here, we investigated if this action of nicotine is also reflected in a chronic treatment regimen.

Original language	English
Journal	Psychopharmacology
Volume	205
Issue number	3
Pages (from-to)	517-28
Number of pages	12
ISSN	0033-3158
DOIs	https://doi.org/10.1007/s00213-009-1560-1
Publication status	Published - 1 Aug 2009

Keywords

Animals
Antidepressive Agents
Behavior, Animal
Bicyclo Compounds, Heterocyclic
Binding Sites
Brain
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Mice
Mice, Inbred Strains
Motor Activity
Nicotine
Nicotinic Agonists
Norepinephrine
Pyridines
Radioligand Assay
Receptors, Nicotinic
Serotonin
Stress, Psychological

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title = "Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test",

abstract = "Smoking rates among depressed individuals is higher than among healthy subjects, and nicotine alleviates depressive symptoms. Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. In mice, acute nicotine administration enhances the activity of antidepressants in the mouse forced swim (mFST) and tail suspension tests. Here, we investigated if this action of nicotine is also reflected in a chronic treatment regimen.",

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AU - Andreasen T., Jesper

AU - Nielsen, Elsebet O

AU - Redrobe, John P

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Smoking rates among depressed individuals is higher than among healthy subjects, and nicotine alleviates depressive symptoms. Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. In mice, acute nicotine administration enhances the activity of antidepressants in the mouse forced swim (mFST) and tail suspension tests. Here, we investigated if this action of nicotine is also reflected in a chronic treatment regimen.

AB - Smoking rates among depressed individuals is higher than among healthy subjects, and nicotine alleviates depressive symptoms. Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. In mice, acute nicotine administration enhances the activity of antidepressants in the mouse forced swim (mFST) and tail suspension tests. Here, we investigated if this action of nicotine is also reflected in a chronic treatment regimen.

KW - Animals

KW - Antidepressive Agents

KW - Behavior, Animal

KW - Bicyclo Compounds, Heterocyclic

KW - Binding Sites

KW - Brain

KW - Disease Models, Animal

KW - Dose-Response Relationship, Drug

KW - Female

KW - Mice

KW - Mice, Inbred Strains

KW - Motor Activity

KW - Nicotine

KW - Nicotinic Agonists

KW - Norepinephrine

KW - Pyridines

KW - Radioligand Assay

KW - Receptors, Nicotinic

KW - Serotonin

KW - Stress, Psychological

U2 - 10.1007/s00213-009-1560-1

DO - 10.1007/s00213-009-1560-1

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SN - 0033-3158

VL - 205

SP - 517

EP - 528

JO - Psychopharmacology

JF - Psychopharmacology

IS - 3

ER -

Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test

Abstract

Keywords

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