@article{dc794808c46643bab61686107ea6bcd3,
title = "Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test",
abstract = "Smoking rates among depressed individuals is higher than among healthy subjects, and nicotine alleviates depressive symptoms. Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. In mice, acute nicotine administration enhances the activity of antidepressants in the mouse forced swim (mFST) and tail suspension tests. Here, we investigated if this action of nicotine is also reflected in a chronic treatment regimen.",
keywords = "Animals, Antidepressive Agents, Behavior, Animal, Bicyclo Compounds, Heterocyclic, Binding Sites, Brain, Disease Models, Animal, Dose-Response Relationship, Drug, Female, Mice, Mice, Inbred Strains, Motor Activity, Nicotine, Nicotinic Agonists, Norepinephrine, Pyridines, Radioligand Assay, Receptors, Nicotinic, Serotonin, Stress, Psychological",
author = "{Andreasen T.}, Jesper and Nielsen, {Elsebet O} and Redrobe, {John P}",
year = "2009",
month = aug,
day = "1",
doi = "10.1007/s00213-009-1560-1",
language = "English",
volume = "205",
pages = "517--28",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer",
number = "3",
}