Chronic obstructive pulmonary disease in alpha1-antitrypsin PI MZ heterozygotes: a meta-analysis

C P Hersh; Morten Dahl; N P Ly; C S Berkey; B G Nordestgaard; E K Silverman

doi:10.1136/thx.2004.022541

Chronic obstructive pulmonary disease in alpha1-antitrypsin PI MZ heterozygotes: a meta-analysis

C P Hersh, Morten Dahl, N P Ly, C S Berkey, B G Nordestgaard, E K Silverman

144 Citations (Scopus)

Abstract

Severe alpha(1)-antitrypsin deficiency, usually related to homozygosity for the protease inhibitor (PI) Z allele, is a proven genetic risk factor for chronic obstructive pulmonary disease (COPD). The risk of COPD in PI MZ heterozygous individuals is controversial.

Original language	English
Journal	Thorax
Volume	59
Issue number	10
Pages (from-to)	843-9
Number of pages	7
ISSN	0040-6376
DOIs	https://doi.org/10.1136/thx.2004.022541
Publication status	Published - Oct 2004

Keywords

Forced Expiratory Volume
Heterozygote
Humans
Odds Ratio
Pulmonary Disease, Chronic Obstructive
alpha 1-Antitrypsin

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10.1136/thx.2004.022541

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title = "Chronic obstructive pulmonary disease in alpha1-antitrypsin PI MZ heterozygotes: a meta-analysis",

abstract = "Severe alpha(1)-antitrypsin deficiency, usually related to homozygosity for the protease inhibitor (PI) Z allele, is a proven genetic risk factor for chronic obstructive pulmonary disease (COPD). The risk of COPD in PI MZ heterozygous individuals is controversial.",

keywords = "Forced Expiratory Volume, Heterozygote, Humans, Odds Ratio, Pulmonary Disease, Chronic Obstructive, alpha 1-Antitrypsin",

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T1 - Chronic obstructive pulmonary disease in alpha1-antitrypsin PI MZ heterozygotes

T2 - a meta-analysis

AU - Hersh, C P

AU - Dahl, Morten

AU - Ly, N P

AU - Berkey, C S

AU - Nordestgaard, B G

AU - Silverman, E K

PY - 2004/10

Y1 - 2004/10

N2 - Severe alpha(1)-antitrypsin deficiency, usually related to homozygosity for the protease inhibitor (PI) Z allele, is a proven genetic risk factor for chronic obstructive pulmonary disease (COPD). The risk of COPD in PI MZ heterozygous individuals is controversial.

AB - Severe alpha(1)-antitrypsin deficiency, usually related to homozygosity for the protease inhibitor (PI) Z allele, is a proven genetic risk factor for chronic obstructive pulmonary disease (COPD). The risk of COPD in PI MZ heterozygous individuals is controversial.

KW - Forced Expiratory Volume

KW - Heterozygote

KW - Humans

KW - Odds Ratio

KW - Pulmonary Disease, Chronic Obstructive

KW - alpha 1-Antitrypsin

U2 - 10.1136/thx.2004.022541

DO - 10.1136/thx.2004.022541

M3 - Journal article

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SN - 0040-6376

VL - 59

SP - 843

EP - 849

JO - Thorax

JF - Thorax

IS - 10

ER -

Chronic obstructive pulmonary disease in alpha1-antitrypsin PI MZ heterozygotes: a meta-analysis

Abstract

Keywords

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