TY - JOUR
T1 - Chromatin Repressive Complexes in Stem Cells, Development, and Cancer
AU - Laugesen, Anne
AU - Helin, Kristian
N1 - Copyright © 2014 Elsevier Inc. All rights reserved.
PY - 2014/6/5
Y1 - 2014/6/5
N2 - The chromatin environment is essential for the correct specification and preservation of cell identity through modulation and maintenance of transcription patterns. Many chromatin regulators are required for development, stem cell maintenance, and differentiation. Here, we review the roles of the polycomb repressive complexes, PRC1 and PRC2, and the HDAC1- and HDAC2-containing complexes, NuRD, Sin3, and CoREST, in stem cells, development, and cancer, as well as the ongoing efforts to develop therapies targeting these complexes in human cancer. Furthermore, we discuss the role of repressive complexes in modulating thresholds for gene activation and their importance for specification and maintenance of cell fate.
AB - The chromatin environment is essential for the correct specification and preservation of cell identity through modulation and maintenance of transcription patterns. Many chromatin regulators are required for development, stem cell maintenance, and differentiation. Here, we review the roles of the polycomb repressive complexes, PRC1 and PRC2, and the HDAC1- and HDAC2-containing complexes, NuRD, Sin3, and CoREST, in stem cells, development, and cancer, as well as the ongoing efforts to develop therapies targeting these complexes in human cancer. Furthermore, we discuss the role of repressive complexes in modulating thresholds for gene activation and their importance for specification and maintenance of cell fate.
U2 - 10.1016/j.stem.2014.05.006
DO - 10.1016/j.stem.2014.05.006
M3 - Review
C2 - 24905164
SN - 1934-5909
VL - 14
SP - 735
EP - 751
JO - Cell Stem Cell
JF - Cell Stem Cell
IS - 6
ER -
