Chromatin Repressive Complexes in Stem Cells, Development, and Cancer

TY - JOUR

T1 - Chromatin Repressive Complexes in Stem Cells, Development, and Cancer

AU - Laugesen, Anne

AU - Helin, Kristian

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2014/6/5

Y1 - 2014/6/5

N2 - The chromatin environment is essential for the correct specification and preservation of cell identity through modulation and maintenance of transcription patterns. Many chromatin regulators are required for development, stem cell maintenance, and differentiation. Here, we review the roles of the polycomb repressive complexes, PRC1 and PRC2, and the HDAC1- and HDAC2-containing complexes, NuRD, Sin3, and CoREST, in stem cells, development, and cancer, as well as the ongoing efforts to develop therapies targeting these complexes in human cancer. Furthermore, we discuss the role of repressive complexes in modulating thresholds for gene activation and their importance for specification and maintenance of cell fate.

AB - The chromatin environment is essential for the correct specification and preservation of cell identity through modulation and maintenance of transcription patterns. Many chromatin regulators are required for development, stem cell maintenance, and differentiation. Here, we review the roles of the polycomb repressive complexes, PRC1 and PRC2, and the HDAC1- and HDAC2-containing complexes, NuRD, Sin3, and CoREST, in stem cells, development, and cancer, as well as the ongoing efforts to develop therapies targeting these complexes in human cancer. Furthermore, we discuss the role of repressive complexes in modulating thresholds for gene activation and their importance for specification and maintenance of cell fate.

U2 - 10.1016/j.stem.2014.05.006

DO - 10.1016/j.stem.2014.05.006

M3 - Review

C2 - 24905164

SN - 1934-5909

VL - 14

SP - 735

EP - 751

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 6

ER -