Choreography of recombination proteins during the DNA damage response

Michael Lisby; Rodney Rothstein

doi:10.1016/j.dnarep.2009.04.007

Choreography of recombination proteins during the DNA damage response

Michael Lisby, Rodney Rothstein

Functional Genomics

86 Citations (Scopus)

Abstract

Genome integrity is frequently challenged by DNA lesions from both endogenous and exogenous sources. A single DNA double-strand break (DSB) is lethal if unrepaired and may lead to loss of heterozygosity, mutations, deletions, genomic rearrangements and chromosome loss if repaired improperly. Such genetic alterations are the main causes of cancer and other genetic diseases. Consequently, DNA double-strand break repair (DSBR) is an important process in all living organisms. DSBR is also the driving mechanism in most strategies of gene targeting, which has applications in both genetic and clinical research. Here we review the cell biological response to DSBs in mitotically growing cells with an emphasis on homologous recombination pathways in yeast Saccharomyces cerevisiae and in mammalian cells.

Original language	English
Journal	DNA Repair
Volume	8
Issue number	9
Pages (from-to)	1068-76
Number of pages	8
ISSN	1568-7864
DOIs	https://doi.org/10.1016/j.dnarep.2009.04.007
Publication status	Published - 2009

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10.1016/j.dnarep.2009.04.007

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@article{e93c53b0f3a211deba73000ea68e967b,

title = "Choreography of recombination proteins during the DNA damage response",

abstract = "Genome integrity is frequently challenged by DNA lesions from both endogenous and exogenous sources. A single DNA double-strand break (DSB) is lethal if unrepaired and may lead to loss of heterozygosity, mutations, deletions, genomic rearrangements and chromosome loss if repaired improperly. Such genetic alterations are the main causes of cancer and other genetic diseases. Consequently, DNA double-strand break repair (DSBR) is an important process in all living organisms. DSBR is also the driving mechanism in most strategies of gene targeting, which has applications in both genetic and clinical research. Here we review the cell biological response to DSBs in mitotically growing cells with an emphasis on homologous recombination pathways in yeast Saccharomyces cerevisiae and in mammalian cells.",

author = "Michael Lisby and Rodney Rothstein",

note = "Keywords: Animals; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Humans; Nuclear Proteins; Recombination, Genetic; Signal Transduction",

year = "2009",

doi = "10.1016/j.dnarep.2009.04.007",

language = "English",

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T1 - Choreography of recombination proteins during the DNA damage response

AU - Lisby, Michael

AU - Rothstein, Rodney

N1 - Keywords: Animals; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Humans; Nuclear Proteins; Recombination, Genetic; Signal Transduction

PY - 2009

Y1 - 2009

N2 - Genome integrity is frequently challenged by DNA lesions from both endogenous and exogenous sources. A single DNA double-strand break (DSB) is lethal if unrepaired and may lead to loss of heterozygosity, mutations, deletions, genomic rearrangements and chromosome loss if repaired improperly. Such genetic alterations are the main causes of cancer and other genetic diseases. Consequently, DNA double-strand break repair (DSBR) is an important process in all living organisms. DSBR is also the driving mechanism in most strategies of gene targeting, which has applications in both genetic and clinical research. Here we review the cell biological response to DSBs in mitotically growing cells with an emphasis on homologous recombination pathways in yeast Saccharomyces cerevisiae and in mammalian cells.

AB - Genome integrity is frequently challenged by DNA lesions from both endogenous and exogenous sources. A single DNA double-strand break (DSB) is lethal if unrepaired and may lead to loss of heterozygosity, mutations, deletions, genomic rearrangements and chromosome loss if repaired improperly. Such genetic alterations are the main causes of cancer and other genetic diseases. Consequently, DNA double-strand break repair (DSBR) is an important process in all living organisms. DSBR is also the driving mechanism in most strategies of gene targeting, which has applications in both genetic and clinical research. Here we review the cell biological response to DSBs in mitotically growing cells with an emphasis on homologous recombination pathways in yeast Saccharomyces cerevisiae and in mammalian cells.

U2 - 10.1016/j.dnarep.2009.04.007

DO - 10.1016/j.dnarep.2009.04.007

M3 - Journal article

C2 - 19473884

SN - 1568-7864

VL - 8

SP - 1068

EP - 1076

JO - DNA Repair

JF - DNA Repair

IS - 9

ER -

Choreography of recombination proteins during the DNA damage response

Abstract

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