Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

Jesus M Banales; Vincenzo Cardinale; Guido Carpino; Marco Marzioni; Jesper B Andersen; Pietro Invernizzi; Guro E Lind; Trine Folseraas; Stuart J Forbes; Laura Fouassier; Andreas Geier; Diego F Calvisi; Joachim C Mertens; Michael Trauner; Antonio Benedetti; Luca Maroni; Javier Vaquero; Rocio I R Macias; Chiara Raggi; Maria J Perugorria; Eugenio Gaudio; Kirsten M Boberg; Jose J G Marin; Domenico Alvaro

doi:10.1038/nrgastro.2016.51

Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

Jesus M Banales, Vincenzo Cardinale, Guido Carpino, Marco Marzioni, Jesper B Andersen, Pietro Invernizzi, Guro E Lind, Trine Folseraas, Stuart J Forbes, Laura Fouassier, Andreas Geier, Diego F Calvisi, Joachim C Mertens, Michael Trauner, Antonio Benedetti, Luca Maroni, Javier Vaquero, Rocio I R Macias, Chiara Raggi, Maria J PerugorriaEugenio Gaudio, Kirsten M Boberg, Jose J G Marin, Domenico Alvaro

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Abstract

Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of biliary tract differentiation. CCA is the second most common primary liver tumour and the incidence is increasing worldwide. CCA has high mortality owing to its aggressiveness, late diagnosis and refractory nature. In May 2015, the "European Network for the Study of Cholangiocarcinoma" (ENS-CCA: www.enscca.org or www.cholangiocarcinoma.eu) was created to promote and boost international research collaboration on the study of CCA at basic, translational and clinical level. In this Consensus Statement, we aim to provide valuable information on classifications, pathological features, risk factors, cells of origin, genetic and epigenetic modifications and current therapies available for this cancer. Moreover, future directions on basic and clinical investigations and plans for the ENS-CCA are highlighted.

Original language	English
Journal	Nature Reviews. Gastroenterology & Hepatology
Volume	13
Issue number	5
Pages (from-to)	261-80
Number of pages	20
ISSN	1759-5045
DOIs	https://doi.org/10.1038/nrgastro.2016.51
Publication status	Published - May 2016

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10.1038/nrgastro.2016.51Licence: CC BY

Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)Final published version, 5.11 MBLicence: CC BY

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Banales, J. M., Cardinale, V., Carpino, G., Marzioni, M., Andersen, J. B., Invernizzi, P., Lind, G. E., Folseraas, T., Forbes, S. J., Fouassier, L., Geier, A., Calvisi, D. F., Mertens, J. C., Trauner, M., Benedetti, A., Maroni, L., Vaquero, J., Macias, R. I. R., Raggi, C., ... Alvaro, D. (2016). Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA). Nature Reviews. Gastroenterology & Hepatology, 13(5), 261-80. https://doi.org/10.1038/nrgastro.2016.51

Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA). / Banales, Jesus M; Cardinale, Vincenzo; Carpino, Guido et al.
In: Nature Reviews. Gastroenterology & Hepatology, Vol. 13, No. 5, 05.2016, p. 261-80.

Research output: Contribution to journal › Review › peer-review

Banales, JM, Cardinale, V, Carpino, G, Marzioni, M, Andersen, JB, Invernizzi, P, Lind, GE, Folseraas, T, Forbes, SJ, Fouassier, L, Geier, A, Calvisi, DF, Mertens, JC, Trauner, M, Benedetti, A, Maroni, L, Vaquero, J, Macias, RIR, Raggi, C, Perugorria, MJ, Gaudio, E, Boberg, KM, Marin, JJG & Alvaro, D 2016, 'Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)', Nature Reviews. Gastroenterology & Hepatology, vol. 13, no. 5, pp. 261-80. https://doi.org/10.1038/nrgastro.2016.51

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abstract = "Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of biliary tract differentiation. CCA is the second most common primary liver tumour and the incidence is increasing worldwide. CCA has high mortality owing to its aggressiveness, late diagnosis and refractory nature. In May 2015, the {"}European Network for the Study of Cholangiocarcinoma{"} (ENS-CCA: www.enscca.org or www.cholangiocarcinoma.eu) was created to promote and boost international research collaboration on the study of CCA at basic, translational and clinical level. In this Consensus Statement, we aim to provide valuable information on classifications, pathological features, risk factors, cells of origin, genetic and epigenetic modifications and current therapies available for this cancer. Moreover, future directions on basic and clinical investigations and plans for the ENS-CCA are highlighted.",

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AU - Banales, Jesus M

AU - Cardinale, Vincenzo

AU - Carpino, Guido

AU - Marzioni, Marco

AU - Andersen, Jesper B

AU - Invernizzi, Pietro

AU - Lind, Guro E

AU - Folseraas, Trine

AU - Forbes, Stuart J

AU - Fouassier, Laura

AU - Geier, Andreas

AU - Calvisi, Diego F

AU - Mertens, Joachim C

AU - Trauner, Michael

AU - Benedetti, Antonio

AU - Maroni, Luca

AU - Vaquero, Javier

AU - Macias, Rocio I R

AU - Raggi, Chiara

AU - Perugorria, Maria J

AU - Gaudio, Eugenio

AU - Boberg, Kirsten M

AU - Marin, Jose J G

AU - Alvaro, Domenico

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N2 - Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of biliary tract differentiation. CCA is the second most common primary liver tumour and the incidence is increasing worldwide. CCA has high mortality owing to its aggressiveness, late diagnosis and refractory nature. In May 2015, the "European Network for the Study of Cholangiocarcinoma" (ENS-CCA: www.enscca.org or www.cholangiocarcinoma.eu) was created to promote and boost international research collaboration on the study of CCA at basic, translational and clinical level. In this Consensus Statement, we aim to provide valuable information on classifications, pathological features, risk factors, cells of origin, genetic and epigenetic modifications and current therapies available for this cancer. Moreover, future directions on basic and clinical investigations and plans for the ENS-CCA are highlighted.

AB - Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of biliary tract differentiation. CCA is the second most common primary liver tumour and the incidence is increasing worldwide. CCA has high mortality owing to its aggressiveness, late diagnosis and refractory nature. In May 2015, the "European Network for the Study of Cholangiocarcinoma" (ENS-CCA: www.enscca.org or www.cholangiocarcinoma.eu) was created to promote and boost international research collaboration on the study of CCA at basic, translational and clinical level. In this Consensus Statement, we aim to provide valuable information on classifications, pathological features, risk factors, cells of origin, genetic and epigenetic modifications and current therapies available for this cancer. Moreover, future directions on basic and clinical investigations and plans for the ENS-CCA are highlighted.

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JO - Nature Reviews. Gastroenterology & Hepatology

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IS - 5

ER -

Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

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