Childhood asthma after bacterial colonization of the airway in neonates

H. Bisgaard; M.N. Hermansen; F. Buchvald; L. Loland; L.B. Halkjaer; Klaus Bønnelykke; Marie Sørensen Brasholt; A. Heltberg; N.H. Vissing; S.V. Thorsen; M. Stage; C.B. Pipper; Hans Bisgaard; Mette Northman Hermansen; Frederik Buchvald; Lotte Loland; Liselotte Brydensholt Halkjaer; Klaus Bønnelykke; Martin Brasholt; Andreas Heltberg; Nadja Hawwa Vissing; Sannie Vester Thorsen; Malene Stage; Christian Bressen Pipper

doi:http://dx.doi.org/10.1056/NEJMoa052632

Childhood asthma after bacterial colonization of the airway in neonates

H. Bisgaard, M.N. Hermansen, F. Buchvald, L. Loland, L.B. Halkjaer, Klaus Bønnelykke, Marie Sørensen Brasholt, A. Heltberg, N.H. Vissing, S.V. Thorsen, M. Stage, C.B. Pipper, Hans Bisgaard, Mette Northman Hermansen, Frederik Buchvald, Lotte Loland, Liselotte Brydensholt Halkjaer, Klaus Bønnelykke, Martin Brasholt, Andreas HeltbergNadja Hawwa Vissing, Sannie Vester Thorsen, Malene Stage, Christian Bressen Pipper

Department of Clinical Medicine

660 Citations (Scopus)

Abstract

Pathological features of the airway in young children with severe recurrent wheeze suggest an association between bacterial colonization and the initiating events of early asthma. We conducted a study to investigate a possible association between bacterial colonization of the hypopharynx in asymptomatic neonates and later development of recurrent wheeze, asthma, and allergy during the first 5 years of life.

Original language	English
Journal	New England Journal of Medicine
Volume	357
Issue number	15
Pages (from-to)	1487-95
Number of pages	9
ISSN	0028-4793
DOIs	https://doi.org/10.1056/NEJMoa052632
Publication status	Published - 11 Oct 2007

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Bisgaard, H., Hermansen, M. N., Buchvald, F., Loland, L., Halkjaer, L. B., Bønnelykke, K., Brasholt, M. S., Heltberg, A., Vissing, N. H., Thorsen, S. V., Stage, M., Pipper, C. B., Bisgaard, H., Hermansen, M. N., Buchvald, F., Loland, L., Halkjaer, L. B., Bønnelykke, K., Brasholt, M., ... Pipper, C. B. (2007). Childhood asthma after bacterial colonization of the airway in neonates. New England Journal of Medicine, 357(15), 1487-95. https://doi.org/10.1056/NEJMoa052632

Bisgaard, H, Hermansen, MN, Buchvald, F, Loland, L, Halkjaer, LB, Bønnelykke, K, Brasholt, MS, Heltberg, A, Vissing, NH, Thorsen, SV, Stage, M, Pipper, CB, Bisgaard, H, Hermansen, MN, Buchvald, F, Loland, L, Halkjaer, LB, Bønnelykke, K, Brasholt, M, Heltberg, A, Vissing, NH, Thorsen, SV, Stage, M & Pipper, CB 2007, 'Childhood asthma after bacterial colonization of the airway in neonates', New England Journal of Medicine, vol. 357, no. 15, pp. 1487-95. https://doi.org/10.1056/NEJMoa052632

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title = "Childhood asthma after bacterial colonization of the airway in neonates",

abstract = "Pathological features of the airway in young children with severe recurrent wheeze suggest an association between bacterial colonization and the initiating events of early asthma. We conducted a study to investigate a possible association between bacterial colonization of the hypopharynx in asymptomatic neonates and later development of recurrent wheeze, asthma, and allergy during the first 5 years of life.",

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T1 - Childhood asthma after bacterial colonization of the airway in neonates

AU - Bisgaard, H.

AU - Hermansen, M.N.

AU - Buchvald, F.

AU - Loland, L.

AU - Halkjaer, L.B.

AU - Bønnelykke, Klaus

AU - Brasholt, Marie Sørensen

AU - Heltberg, A.

AU - Vissing, N.H.

AU - Thorsen, S.V.

AU - Stage, M.

AU - Pipper, C.B.

AU - Bisgaard, Hans

AU - Hermansen, Mette Northman

AU - Buchvald, Frederik

AU - Loland, Lotte

AU - Halkjaer, Liselotte Brydensholt

AU - Bønnelykke, Klaus

AU - Brasholt, Martin

AU - Heltberg, Andreas

AU - Vissing, Nadja Hawwa

AU - Thorsen, Sannie Vester

AU - Stage, Malene

AU - Pipper, Christian Bressen

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AB - Pathological features of the airway in young children with severe recurrent wheeze suggest an association between bacterial colonization and the initiating events of early asthma. We conducted a study to investigate a possible association between bacterial colonization of the hypopharynx in asymptomatic neonates and later development of recurrent wheeze, asthma, and allergy during the first 5 years of life.

U2 - http://dx.doi.org/10.1056/NEJMoa052632

DO - http://dx.doi.org/10.1056/NEJMoa052632

M3 - Journal article

SN - 0028-4793

VL - 357

SP - 1487

EP - 1495

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 15

ER -

Childhood asthma after bacterial colonization of the airway in neonates

Abstract

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