Abstract
We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.
| Original language | English |
|---|---|
| Journal | Journal of Neuroimmunology |
| Volume | 122 |
| Issue number | 1-2 |
| Pages (from-to) | 125-31 |
| Number of pages | 7 |
| ISSN | 0165-5728 |
| Publication status | Published - Jan 2002 |
Keywords
- Adjuvants, Immunologic
- Adult
- B-Lymphocytes
- Cerebrospinal Fluid
- Demyelinating Diseases
- Female
- Flow Cytometry
- Humans
- Interferon-beta
- Male
- Middle Aged
- Multiple Sclerosis, Chronic Progressive
- Multiple Sclerosis, Relapsing-Remitting
- Receptors, CCR5
- Receptors, CXCR3
- Receptors, CXCR5
- Receptors, Chemokine
- Receptors, Cytokine