Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis

Torben Lykke Sørensen; Hanne Roed; Finn Sellebjerg

Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis

Torben Lykke Sørensen, Hanne Roed, Finn Sellebjerg

Institut for Klinisk Medicin

32 Citationer (Scopus)

Abstract

We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.

Originalsprog	Engelsk
Tidsskrift	Journal of Neuroimmunology
Vol/bind	122
Udgave nummer	1-2
Sider (fra-til)	125-31
Antal sider	7
ISSN	0165-5728
Status	Udgivet - jan. 2002

Citationsformater

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title = "Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis",

abstract = "We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.",

keywords = "Adjuvants, Immunologic, Adult, B-Lymphocytes, Cerebrospinal Fluid, Demyelinating Diseases, Female, Flow Cytometry, Humans, Interferon-beta, Male, Middle Aged, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting, Receptors, CCR5, Receptors, CXCR3, Receptors, CXCR5, Receptors, Chemokine, Receptors, Cytokine",

author = "S{\o}rensen, {Torben Lykke} and Hanne Roed and Finn Sellebjerg",

year = "2002",

month = jan,

language = "English",

volume = "122",

pages = "125--31",

journal = "Journal of Neuroimmunology",

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TY - JOUR

T1 - Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis

AU - Sørensen, Torben Lykke

AU - Roed, Hanne

AU - Sellebjerg, Finn

PY - 2002/1

Y1 - 2002/1

N2 - We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.

AB - We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.

KW - Adjuvants, Immunologic

KW - Adult

KW - B-Lymphocytes

KW - Cerebrospinal Fluid

KW - Demyelinating Diseases

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Interferon-beta

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis, Chronic Progressive

KW - Multiple Sclerosis, Relapsing-Remitting

KW - Receptors, CCR5

KW - Receptors, CXCR3

KW - Receptors, CXCR5

KW - Receptors, Chemokine

KW - Receptors, Cytokine

M3 - Journal article

C2 - 11777551

SN - 0165-5728

VL - 122

SP - 125

EP - 131

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis

Abstract

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Citationsformater