Chemogenomics of allosteric binding sites in GPCRs

David E. Gloriam

doi:10.1016/j.ddtec.2012.07.010

Chemogenomics of allosteric binding sites in GPCRs

10 Citations (Scopus)

Abstract

Chemogenomic techniques connect the chemical and biological domains to establish ligand and target relationships not evident from the individual disciplines. Chemogenomics has been applied in lead generation, target classification, focused library design as well as selectivity and polypharmacology profiling. This review describes recent developments structured into ligand-, target- and combined chemogenomic techniques and applications to allosteric GPCR ligands. It also outlines relative strengths and limitations of these techniques and the impact of the increasing crystallographic data.

Original language	English
Journal	Drug Discovery Today: Technologies
Volume	10
Issue number	2
Pages (from-to)	e307-13
ISSN	1740-6749
DOIs	https://doi.org/10.1016/j.ddtec.2012.07.010
Publication status	Published - 2013

Access to Document

10.1016/j.ddtec.2012.07.010

Cite this

@article{9598cae8a09a485ca26c4a5fddb29e10,

title = "Chemogenomics of allosteric binding sites in GPCRs",

abstract = "Chemogenomic techniques connect the chemical and biological domains to establish ligand and target relationships not evident from the individual disciplines. Chemogenomics has been applied in lead generation, target classification, focused library design as well as selectivity and polypharmacology profiling. This review describes recent developments structured into ligand-, target- and combined chemogenomic techniques and applications to allosteric GPCR ligands. It also outlines relative strengths and limitations of these techniques and the impact of the increasing crystallographic data.",

author = "Gloriam, {David E.}",

year = "2013",

doi = "10.1016/j.ddtec.2012.07.010",

language = "English",

volume = "10",

pages = "e307--13",

journal = "Drug Discovery Today: Technologies",

issn = "1740-6749",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Chemogenomics of allosteric binding sites in GPCRs

AU - Gloriam, David E.

PY - 2013

Y1 - 2013

N2 - Chemogenomic techniques connect the chemical and biological domains to establish ligand and target relationships not evident from the individual disciplines. Chemogenomics has been applied in lead generation, target classification, focused library design as well as selectivity and polypharmacology profiling. This review describes recent developments structured into ligand-, target- and combined chemogenomic techniques and applications to allosteric GPCR ligands. It also outlines relative strengths and limitations of these techniques and the impact of the increasing crystallographic data.

AB - Chemogenomic techniques connect the chemical and biological domains to establish ligand and target relationships not evident from the individual disciplines. Chemogenomics has been applied in lead generation, target classification, focused library design as well as selectivity and polypharmacology profiling. This review describes recent developments structured into ligand-, target- and combined chemogenomic techniques and applications to allosteric GPCR ligands. It also outlines relative strengths and limitations of these techniques and the impact of the increasing crystallographic data.

U2 - 10.1016/j.ddtec.2012.07.010

DO - 10.1016/j.ddtec.2012.07.010

M3 - Journal article

C2 - 24050282

SN - 1740-6749

VL - 10

SP - e307-13

JO - Drug Discovery Today: Technologies

JF - Drug Discovery Today: Technologies

IS - 2

ER -

Chemogenomics of allosteric binding sites in GPCRs

Abstract

Access to Document

Fingerprint

Cite this