Chemogenomics of allosteric binding sites in GPCRs

David E. Gloriam

doi:10.1016/j.ddtec.2012.07.010

Chemogenomics of allosteric binding sites in GPCRs

10 Citationer (Scopus)

Abstract

Chemogenomic techniques connect the chemical and biological domains to establish ligand and target relationships not evident from the individual disciplines. Chemogenomics has been applied in lead generation, target classification, focused library design as well as selectivity and polypharmacology profiling. This review describes recent developments structured into ligand-, target- and combined chemogenomic techniques and applications to allosteric GPCR ligands. It also outlines relative strengths and limitations of these techniques and the impact of the increasing crystallographic data.

Originalsprog	Engelsk
Tidsskrift	Drug Discovery Today: Technologies
Vol/bind	10
Udgave nummer	2
Sider (fra-til)	e307-13
ISSN	1740-6749
DOI	https://doi.org/10.1016/j.ddtec.2012.07.010
Status	Udgivet - 2013

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10.1016/j.ddtec.2012.07.010

Citationsformater

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AB - Chemogenomic techniques connect the chemical and biological domains to establish ligand and target relationships not evident from the individual disciplines. Chemogenomics has been applied in lead generation, target classification, focused library design as well as selectivity and polypharmacology profiling. This review describes recent developments structured into ligand-, target- and combined chemogenomic techniques and applications to allosteric GPCR ligands. It also outlines relative strengths and limitations of these techniques and the impact of the increasing crystallographic data.

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M3 - Journal article

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SP - e307-13

JO - Drug Discovery Today: Technologies

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Chemogenomics of allosteric binding sites in GPCRs

Abstract

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