Abstract
Background: Aminoglycoside antibiotics cause misreading during mRNA translation. Results: Aminoglycoside action resulted in misfolding of newly synthesized proteins, and chaperonins helped Escherichia coli cope with this insult. Conclusion: Chaperonins fight aminoglycoside-induced protein misfolding. Significance: The study shows how chaperones can increase bacterial tolerance to aminoglycoside antibiotics.
| Original language | English |
|---|---|
| Journal | The Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 15 |
| Pages (from-to) | 10483-9 |
| Number of pages | 7 |
| ISSN | 0021-9258 |
| DOIs | |
| Publication status | Published - 12 Apr 2013 |
Keywords
- Aminoglycosides
- Chaperonin 10
- Chaperonin 60
- Drug Resistance, Bacterial
- Escherichia coli
- Escherichia coli Proteins
- HSP40 Heat-Shock Proteins
- HSP70 Heat-Shock Proteins
- Heat-Shock Proteins
- Protein Folding