Chaperonins fight aminoglycoside-induced protein misfolding and promote short-term tolerance in Escherichia coli

Lise Goltermann; Liam Good; Thomas Bentin

doi:10.1074/jbc.M112.420380

Chaperonins fight aminoglycoside-induced protein misfolding and promote short-term tolerance in Escherichia coli

Lise Goltermann, Liam Good, Thomas Bentin

Transcription, RNA, and Gene Medicine Program

43 Citationer (Scopus)

Abstract

Background: Aminoglycoside antibiotics cause misreading during mRNA translation. Results: Aminoglycoside action resulted in misfolding of newly synthesized proteins, and chaperonins helped Escherichia coli cope with this insult. Conclusion: Chaperonins fight aminoglycoside-induced protein misfolding. Significance: The study shows how chaperones can increase bacterial tolerance to aminoglycoside antibiotics.

Originalsprog	Engelsk
Tidsskrift	The Journal of Biological Chemistry
Vol/bind	288
Udgave nummer	15
Sider (fra-til)	10483-9
Antal sider	7
ISSN	0021-9258
DOI	https://doi.org/10.1074/jbc.M112.420380
Status	Udgivet - 12 apr. 2013

Adgang til dokumentet

10.1074/jbc.M112.420380

Citationsformater

@article{e0370cf9afc5407d9cbbe9c72d8c3193,

title = "Chaperonins fight aminoglycoside-induced protein misfolding and promote short-term tolerance in Escherichia coli",

abstract = "Background: Aminoglycoside antibiotics cause misreading during mRNA translation. Results: Aminoglycoside action resulted in misfolding of newly synthesized proteins, and chaperonins helped Escherichia coli cope with this insult. Conclusion: Chaperonins fight aminoglycoside-induced protein misfolding. Significance: The study shows how chaperones can increase bacterial tolerance to aminoglycoside antibiotics.",

keywords = "Aminoglycosides, Chaperonin 10, Chaperonin 60, Drug Resistance, Bacterial, Escherichia coli, Escherichia coli Proteins, HSP40 Heat-Shock Proteins, HSP70 Heat-Shock Proteins, Heat-Shock Proteins, Protein Folding",

author = "Lise Goltermann and Liam Good and Thomas Bentin",

year = "2013",

month = apr,

day = "12",

doi = "10.1074/jbc.M112.420380",

language = "English",

volume = "288",

pages = "10483--9",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology, Inc.",

number = "15",

}

TY - JOUR

T1 - Chaperonins fight aminoglycoside-induced protein misfolding and promote short-term tolerance in Escherichia coli

AU - Goltermann, Lise

AU - Good, Liam

AU - Bentin, Thomas

PY - 2013/4/12

Y1 - 2013/4/12

N2 - Background: Aminoglycoside antibiotics cause misreading during mRNA translation. Results: Aminoglycoside action resulted in misfolding of newly synthesized proteins, and chaperonins helped Escherichia coli cope with this insult. Conclusion: Chaperonins fight aminoglycoside-induced protein misfolding. Significance: The study shows how chaperones can increase bacterial tolerance to aminoglycoside antibiotics.

AB - Background: Aminoglycoside antibiotics cause misreading during mRNA translation. Results: Aminoglycoside action resulted in misfolding of newly synthesized proteins, and chaperonins helped Escherichia coli cope with this insult. Conclusion: Chaperonins fight aminoglycoside-induced protein misfolding. Significance: The study shows how chaperones can increase bacterial tolerance to aminoglycoside antibiotics.

KW - Aminoglycosides

KW - Chaperonin 10

KW - Chaperonin 60

KW - Drug Resistance, Bacterial

KW - Escherichia coli

KW - Escherichia coli Proteins

KW - HSP40 Heat-Shock Proteins

KW - HSP70 Heat-Shock Proteins

KW - Heat-Shock Proteins

KW - Protein Folding

U2 - 10.1074/jbc.M112.420380

DO - 10.1074/jbc.M112.420380

M3 - Journal article

C2 - 23447537

SN - 0021-9258

VL - 288

SP - 10483

EP - 10489

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 15

ER -

Chaperonins fight aminoglycoside-induced protein misfolding and promote short-term tolerance in Escherichia coli

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater