Chaperonins fight aminoglycoside-induced protein misfolding and promote short-term tolerance in Escherichia coli

Lise Goltermann; Liam Good; Thomas Bentin

doi:10.1074/jbc.M112.420380

Chaperonins fight aminoglycoside-induced protein misfolding and promote short-term tolerance in Escherichia coli

Lise Goltermann, Liam Good, Thomas Bentin

Transcription, RNA, and Gene Medicine Program

43 Citationer (Scopus)

Abstract

Background: Aminoglycoside antibiotics cause misreading during mRNA translation. Results: Aminoglycoside action resulted in misfolding of newly synthesized proteins, and chaperonins helped Escherichia coli cope with this insult. Conclusion: Chaperonins fight aminoglycoside-induced protein misfolding. Significance: The study shows how chaperones can increase bacterial tolerance to aminoglycoside antibiotics.

Originalsprog	Engelsk
Tidsskrift	The Journal of Biological Chemistry
Vol/bind	288
Udgave nummer	15
Sider (fra-til)	10483-9
Antal sider	7
ISSN	0021-9258
DOI	https://doi.org/10.1074/jbc.M112.420380
Status	Udgivet - 12 apr. 2013

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10.1074/jbc.M112.420380

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title = "Chaperonins fight aminoglycoside-induced protein misfolding and promote short-term tolerance in Escherichia coli",

abstract = "Background: Aminoglycoside antibiotics cause misreading during mRNA translation. Results: Aminoglycoside action resulted in misfolding of newly synthesized proteins, and chaperonins helped Escherichia coli cope with this insult. Conclusion: Chaperonins fight aminoglycoside-induced protein misfolding. Significance: The study shows how chaperones can increase bacterial tolerance to aminoglycoside antibiotics.",

keywords = "Aminoglycosides, Chaperonin 10, Chaperonin 60, Drug Resistance, Bacterial, Escherichia coli, Escherichia coli Proteins, HSP40 Heat-Shock Proteins, HSP70 Heat-Shock Proteins, Heat-Shock Proteins, Protein Folding",

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AU - Goltermann, Lise

AU - Good, Liam

AU - Bentin, Thomas

PY - 2013/4/12

Y1 - 2013/4/12

N2 - Background: Aminoglycoside antibiotics cause misreading during mRNA translation. Results: Aminoglycoside action resulted in misfolding of newly synthesized proteins, and chaperonins helped Escherichia coli cope with this insult. Conclusion: Chaperonins fight aminoglycoside-induced protein misfolding. Significance: The study shows how chaperones can increase bacterial tolerance to aminoglycoside antibiotics.

AB - Background: Aminoglycoside antibiotics cause misreading during mRNA translation. Results: Aminoglycoside action resulted in misfolding of newly synthesized proteins, and chaperonins helped Escherichia coli cope with this insult. Conclusion: Chaperonins fight aminoglycoside-induced protein misfolding. Significance: The study shows how chaperones can increase bacterial tolerance to aminoglycoside antibiotics.

KW - Aminoglycosides

KW - Chaperonin 10

KW - Chaperonin 60

KW - Drug Resistance, Bacterial

KW - Escherichia coli

KW - Escherichia coli Proteins

KW - HSP40 Heat-Shock Proteins

KW - HSP70 Heat-Shock Proteins

KW - Heat-Shock Proteins

KW - Protein Folding

U2 - 10.1074/jbc.M112.420380

DO - 10.1074/jbc.M112.420380

M3 - Journal article

C2 - 23447537

SN - 0021-9258

VL - 288

SP - 10483

EP - 10489

JO - The Journal of Biological Chemistry

JF - The Journal of Biological Chemistry

IS - 15

ER -

Chaperonins fight aminoglycoside-induced protein misfolding and promote short-term tolerance in Escherichia coli

Abstract

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