Changes in the pattern of paracetamol use in the periconception period in a Danish cohort

TY - JOUR

T1 - Changes in the pattern of paracetamol use in the periconception period in a Danish cohort

AU - Ersbøll, Anne S

AU - Hedegaard, Mette

AU - Damm, Peter

AU - Johansen, Marianne

AU - Tabor, Ann

AU - Hegaard, Hanne K

N1 - © 2015 Nordic Federation of Societies of Obstetrics and Gynecology.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Paracetamol is the most commonly used over-the-counter drug in pregnancy. It is generally considered to be safe, but prolonged antenatal exposure has been associated with offspring short-and long-term morbidity. Our aim was to describe the pattern of paracetamol use with a focus on frequent ingestion (more than once a week), 3 months before and in early pregnancy. In this cohort, 8650 pregnant women responded to a web-based clinical questionnaire that included questions about drug use. Paracetamol was the most used drug before and in early pregnancy (35.2% and 6.5% of respondents, respectively). The proportion of frequent users decreased from 3.9% before to 0.9% in early pregnancy. Frequent paracetamol use was associated with smoking, co-morbidities, body mass index ≥25 kg/m2, unplanned pregnancy, no education and inability to understand Danish. A significant decrease in the proportion of women with any paracetamol use in early pregnancy was noted after access to large packs was restricted by legislation.

AB - Paracetamol is the most commonly used over-the-counter drug in pregnancy. It is generally considered to be safe, but prolonged antenatal exposure has been associated with offspring short-and long-term morbidity. Our aim was to describe the pattern of paracetamol use with a focus on frequent ingestion (more than once a week), 3 months before and in early pregnancy. In this cohort, 8650 pregnant women responded to a web-based clinical questionnaire that included questions about drug use. Paracetamol was the most used drug before and in early pregnancy (35.2% and 6.5% of respondents, respectively). The proportion of frequent users decreased from 3.9% before to 0.9% in early pregnancy. Frequent paracetamol use was associated with smoking, co-morbidities, body mass index ≥25 kg/m2, unplanned pregnancy, no education and inability to understand Danish. A significant decrease in the proportion of women with any paracetamol use in early pregnancy was noted after access to large packs was restricted by legislation.

KW - Acetaminophen

KW - Adult

KW - Analgesics, Non-Narcotic

KW - Cohort Studies

KW - Female

KW - Health Behavior

KW - Humans

KW - Pregnancy

KW - Pregnancy Trimester, First

KW - Socioeconomic Factors

KW - Surveys and Questionnaires

KW - Sweden

KW - Young Adult

U2 - 10.1111/aogs.12667

DO - 10.1111/aogs.12667

M3 - Journal article

C2 - 25939806

SN - 0001-6349

VL - 94

SP - 898

EP - 903

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

IS - 8

ER -