Changes in cerebral blood flow after acetazolamide: an experimental study comparing near-infrared spectroscopy and SPECT

TY - JOUR

T1 - Changes in cerebral blood flow after acetazolamide: an experimental study comparing near-infrared spectroscopy and SPECT

AU - Schytz, H W

AU - Wienecke, T

AU - Jensen, L T

AU - Selb, J

AU - Boas, D A

AU - Ashina, M

AU - Schytz, H W

AU - Wienecke, Troels

AU - Jensen, Lars Thorbjørn

AU - Selb, J

AU - Boas, D A

AU - Ashina, M

N1 - Keywords: Acetazolamide; Adolescent; Adult; Arterioles; Brain; Carbonic Anhydrase Inhibitors; Cerebrovascular Circulation; Female; Humans; Indocyanine Green; Injections, Intravenous; Male; Regional Blood Flow; Skin; Spectroscopy, Near-Infrared; Tomography, Emission-Computed, Single-Photon; Xenon Radioisotopes; Young Adult

PY - 2009

Y1 - 2009

N2 - BACKGROUND AND PURPOSE: It is important to find a reliable and bedside method, which can estimate the cerebral blood flow (CBF) of patients in clinical settings. Estimation of CBF by calculating a blood flow index (BFI) using continuous wave near-infrared spectroscopy (CW-NIRS) and indocyanine green (ICG) as an i.v. tracer has been proposed to be a feasible and promising method. To validate if the BFI method can detect relative changes in CBF we compared data with the established method (133)Xenon single photon emission computer tomography ((133)Xe-SPECT). METHODS: Ten healthy subjects were investigated before and after a bolus of acetazolamide. NIRS data were obtained using a multi source detector separation configuration in order to assess a corrected BFI (BFI(corr)) value, which attempts to eliminate contamination of skin blood flow. RESULTS: Data obtained showed no significant correlation between CBF changes measured by (133)Xe-SPECT and BFI(corr) (0.133, P = 0.732). After acetazolamide, a 49% increase in CBF was detected using the (133)Xe-SPECT method, whereas no changes in any ICG variables were observed after acetazolamide. CONCLUSION: The study shows that it is not possible to obtain reliable BFI data, which reflect changes in CBF after acetazolamide infusion, using the CW-NIRS and ICG method.

AB - BACKGROUND AND PURPOSE: It is important to find a reliable and bedside method, which can estimate the cerebral blood flow (CBF) of patients in clinical settings. Estimation of CBF by calculating a blood flow index (BFI) using continuous wave near-infrared spectroscopy (CW-NIRS) and indocyanine green (ICG) as an i.v. tracer has been proposed to be a feasible and promising method. To validate if the BFI method can detect relative changes in CBF we compared data with the established method (133)Xenon single photon emission computer tomography ((133)Xe-SPECT). METHODS: Ten healthy subjects were investigated before and after a bolus of acetazolamide. NIRS data were obtained using a multi source detector separation configuration in order to assess a corrected BFI (BFI(corr)) value, which attempts to eliminate contamination of skin blood flow. RESULTS: Data obtained showed no significant correlation between CBF changes measured by (133)Xe-SPECT and BFI(corr) (0.133, P = 0.732). After acetazolamide, a 49% increase in CBF was detected using the (133)Xe-SPECT method, whereas no changes in any ICG variables were observed after acetazolamide. CONCLUSION: The study shows that it is not possible to obtain reliable BFI data, which reflect changes in CBF after acetazolamide infusion, using the CW-NIRS and ICG method.

U2 - 10.1111/j.1468-1331.2008.02398.x

DO - 10.1111/j.1468-1331.2008.02398.x

M3 - Journal article

C2 - 19236469

SN - 1351-5101

VL - 16

SP - 461

EP - 467

JO - European Journal of Neurology

JF - European Journal of Neurology

IS - 4

ER -