@article{23998a00a69f11df928f000ea68e967b,
title = "Changes in cerebral blood flow after acetazolamide: an experimental study comparing near-infrared spectroscopy and SPECT",
abstract = "BACKGROUND AND PURPOSE: It is important to find a reliable and bedside method, which can estimate the cerebral blood flow (CBF) of patients in clinical settings. Estimation of CBF by calculating a blood flow index (BFI) using continuous wave near-infrared spectroscopy (CW-NIRS) and indocyanine green (ICG) as an i.v. tracer has been proposed to be a feasible and promising method. To validate if the BFI method can detect relative changes in CBF we compared data with the established method (133)Xenon single photon emission computer tomography ((133)Xe-SPECT). METHODS: Ten healthy subjects were investigated before and after a bolus of acetazolamide. NIRS data were obtained using a multi source detector separation configuration in order to assess a corrected BFI (BFI(corr)) value, which attempts to eliminate contamination of skin blood flow. RESULTS: Data obtained showed no significant correlation between CBF changes measured by (133)Xe-SPECT and BFI(corr) (0.133, P = 0.732). After acetazolamide, a 49% increase in CBF was detected using the (133)Xe-SPECT method, whereas no changes in any ICG variables were observed after acetazolamide. CONCLUSION: The study shows that it is not possible to obtain reliable BFI data, which reflect changes in CBF after acetazolamide infusion, using the CW-NIRS and ICG method.",
author = "Schytz, {H W} and T Wienecke and Jensen, {L T} and J Selb and Boas, {D A} and M Ashina and Schytz, {H W} and Troels Wienecke and Jensen, {Lars Thorbj{\o}rn} and J Selb and Boas, {D A} and M Ashina",
note = "Keywords: Acetazolamide; Adolescent; Adult; Arterioles; Brain; Carbonic Anhydrase Inhibitors; Cerebrovascular Circulation; Female; Humans; Indocyanine Green; Injections, Intravenous; Male; Regional Blood Flow; Skin; Spectroscopy, Near-Infrared; Tomography, Emission-Computed, Single-Photon; Xenon Radioisotopes; Young Adult",
year = "2009",
doi = "10.1111/j.1468-1331.2008.02398.x",
language = "English",
volume = "16",
pages = "461--7",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell",
number = "4",
}