Ceramides and barrier function in healthy skin

Jakob Mutanu Jungersted; Lars Hellgren; Julie Kaae Høgh; Tue Drachmann; Gregor Jemec; Tove Agner

doi:http://dx.doi.org/10.2340/00015555-0894

Ceramides and barrier function in healthy skin

Jakob Mutanu Jungersted, Lars Hellgren, Julie Kaae Høgh, Tue Drachmann, Gregor Jemec, Tove Agner

24 Citations (Scopus)

Abstract

Lipids in the stratum corneum are key components in the barrier function of the skin. Changes in lipid composition related to eczematous diseases are well known, but limited data are available on variations within healthy skin. The objective of the present study was to compare ceramide subgroups and ceramide/cholesterol ratios in young, old, male and female healthy skin. A total of 55 participants with healthy skin was included in the study. Lipid profiles were correlated with transepidermal water loss and with information on dry skin from a questionnaire including 16 people. No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02).

Original language	English
Journal	Acta Dermato Venereologica
Volume	90
Issue number	4
Pages (from-to)	350-3
Number of pages	4
ISSN	0001-5555
DOIs	https://doi.org/10.2340/00015555-0894
Publication status	Published - 1 Jul 2010

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title = "Ceramides and barrier function in healthy skin",

abstract = "Lipids in the stratum corneum are key components in the barrier function of the skin. Changes in lipid composition related to eczematous diseases are well known, but limited data are available on variations within healthy skin. The objective of the present study was to compare ceramide subgroups and ceramide/cholesterol ratios in young, old, male and female healthy skin. A total of 55 participants with healthy skin was included in the study. Lipid profiles were correlated with transepidermal water loss and with information on dry skin from a questionnaire including 16 people. No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02).",

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T1 - Ceramides and barrier function in healthy skin

AU - Mutanu Jungersted, Jakob

AU - Hellgren, Lars

AU - Høgh, Julie Kaae

AU - Drachmann, Tue

AU - Jemec, Gregor

AU - Agner, Tove

PY - 2010/7/1

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N2 - Lipids in the stratum corneum are key components in the barrier function of the skin. Changes in lipid composition related to eczematous diseases are well known, but limited data are available on variations within healthy skin. The objective of the present study was to compare ceramide subgroups and ceramide/cholesterol ratios in young, old, male and female healthy skin. A total of 55 participants with healthy skin was included in the study. Lipid profiles were correlated with transepidermal water loss and with information on dry skin from a questionnaire including 16 people. No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02).

AB - Lipids in the stratum corneum are key components in the barrier function of the skin. Changes in lipid composition related to eczematous diseases are well known, but limited data are available on variations within healthy skin. The objective of the present study was to compare ceramide subgroups and ceramide/cholesterol ratios in young, old, male and female healthy skin. A total of 55 participants with healthy skin was included in the study. Lipid profiles were correlated with transepidermal water loss and with information on dry skin from a questionnaire including 16 people. No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02).

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Ceramides and barrier function in healthy skin

Abstract

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