Ceramides and barrier function in healthy skin

Jakob Mutanu Jungersted; Lars Hellgren; Julie Kaae Høgh; Tue Drachmann; Gregor Jemec; Tove Agner

doi:http://dx.doi.org/10.2340/00015555-0894

Ceramides and barrier function in healthy skin

Jakob Mutanu Jungersted, Lars Hellgren, Julie Kaae Høgh, Tue Drachmann, Gregor Jemec, Tove Agner

24 Citationer (Scopus)

Abstract

Lipids in the stratum corneum are key components in the barrier function of the skin. Changes in lipid composition related to eczematous diseases are well known, but limited data are available on variations within healthy skin. The objective of the present study was to compare ceramide subgroups and ceramide/cholesterol ratios in young, old, male and female healthy skin. A total of 55 participants with healthy skin was included in the study. Lipid profiles were correlated with transepidermal water loss and with information on dry skin from a questionnaire including 16 people. No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02).

Originalsprog	Engelsk
Tidsskrift	Acta Dermato Venereologica
Vol/bind	90
Udgave nummer	4
Sider (fra-til)	350-3
Antal sider	4
ISSN	0001-5555
DOI	https://doi.org/10.2340/00015555-0894
Status	Udgivet - 1 jul. 2010

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http://dx.doi.org/10.2340/00015555-0894

Citationsformater

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title = "Ceramides and barrier function in healthy skin",

abstract = "Lipids in the stratum corneum are key components in the barrier function of the skin. Changes in lipid composition related to eczematous diseases are well known, but limited data are available on variations within healthy skin. The objective of the present study was to compare ceramide subgroups and ceramide/cholesterol ratios in young, old, male and female healthy skin. A total of 55 participants with healthy skin was included in the study. Lipid profiles were correlated with transepidermal water loss and with information on dry skin from a questionnaire including 16 people. No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02).",

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T1 - Ceramides and barrier function in healthy skin

AU - Mutanu Jungersted, Jakob

AU - Hellgren, Lars

AU - Høgh, Julie Kaae

AU - Drachmann, Tue

AU - Jemec, Gregor

AU - Agner, Tove

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Lipids in the stratum corneum are key components in the barrier function of the skin. Changes in lipid composition related to eczematous diseases are well known, but limited data are available on variations within healthy skin. The objective of the present study was to compare ceramide subgroups and ceramide/cholesterol ratios in young, old, male and female healthy skin. A total of 55 participants with healthy skin was included in the study. Lipid profiles were correlated with transepidermal water loss and with information on dry skin from a questionnaire including 16 people. No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02).

AB - Lipids in the stratum corneum are key components in the barrier function of the skin. Changes in lipid composition related to eczematous diseases are well known, but limited data are available on variations within healthy skin. The objective of the present study was to compare ceramide subgroups and ceramide/cholesterol ratios in young, old, male and female healthy skin. A total of 55 participants with healthy skin was included in the study. Lipid profiles were correlated with transepidermal water loss and with information on dry skin from a questionnaire including 16 people. No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02).

U2 - http://dx.doi.org/10.2340/00015555-0894

DO - http://dx.doi.org/10.2340/00015555-0894

M3 - Journal article

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EP - 353

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

IS - 4

ER -

Ceramides and barrier function in healthy skin

Abstract

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