C/EBPalpha: a tumour suppressor in multiple tissues?

TY - JOUR

T1 - C/EBPalpha: a tumour suppressor in multiple tissues?

AU - Schuster, Mikkel Bruhn

AU - Porse, Bo Torben

N1 - Keywords: Animals; CCAAT-Enhancer-Binding Protein-alpha; Genes, Tumor Suppressor; Humans; Neoplasms; Tissue Distribution

PY - 2006

Y1 - 2006

N2 - The CCATT/enhancer binding protein alpha, C/EBPalpha, is a key transcription factor involved in late differentiation events of several cell types. Besides acting as a classical transcription factor, C/EBPalpha is also a well-characterized inhibitor of mitotic growth in most cell lines tested. In line with its anti-mitotic properties, C/EBPalpha has been shown to interact with, and alter the activities of, several cell cycle related proteins and a number of models as to the mechanistics of C/EBPalpha-mediated growth repression have been proposed. More recently, several reports have indicated that C/EBPalpha acts as a tumour suppressor in the hematopoietic system and that mutation within C/EBPalpha is sufficient to induce tumourigenesis. Here, we will review these data and probe the possibility that C/EBPalpha also act as a tumour suppressor in other C/EBPalpha-expressing tissues.

AB - The CCATT/enhancer binding protein alpha, C/EBPalpha, is a key transcription factor involved in late differentiation events of several cell types. Besides acting as a classical transcription factor, C/EBPalpha is also a well-characterized inhibitor of mitotic growth in most cell lines tested. In line with its anti-mitotic properties, C/EBPalpha has been shown to interact with, and alter the activities of, several cell cycle related proteins and a number of models as to the mechanistics of C/EBPalpha-mediated growth repression have been proposed. More recently, several reports have indicated that C/EBPalpha acts as a tumour suppressor in the hematopoietic system and that mutation within C/EBPalpha is sufficient to induce tumourigenesis. Here, we will review these data and probe the possibility that C/EBPalpha also act as a tumour suppressor in other C/EBPalpha-expressing tissues.

U2 - 10.1016/j.bbcan.2006.02.003

DO - 10.1016/j.bbcan.2006.02.003

M3 - Journal article

C2 - 16616425

SN - 0304-4165

VL - 1766

SP - 88

EP - 103

JO - BBA General Subjects

JF - BBA General Subjects

IS - 1

ER -