Abstract
BACKGROUND: Adult atopic dermatitis (AD) has been associated with several comorbidities, but cause-specific mortality risk is unknown.
OBJECTIVE: To examine cause-specific death rates and risk in adults with AD.
METHODS: We performed cross-linkage of nationwide health care and cause of death registers. Adult patients with AD were matched with 10 controls per study subject. We calculated incidence rates per 1000 person-years and hazard ratios (HRs) of cause-specific death with 95% confidence intervals (95% CIs) using Cox proportional hazards models.
RESULTS: A total of 8686 patients and 86,860 matched controls were studied. The risk for death due to any cause was significantly increased in patients with AD (HR 1.27, 95%CI 1.11-1.45). Significant causes included cardiovascular (HR 1.45; 95% CI 1.07-1.96), infectious (HR 3.71; 95% CI 1.43-9.60), and urogenital diseases (HR 5.51; 95% CI 1.54-19.80). No increased risk for death due to cancer, endocrine, neurologic, psychiatric, respiratory, or gastroenterologic disease was observed.
LIMITATIONS: The results might not be generalizable to patients seen exclusively by primary care physicians.
CONCLUSION: Adults with atopic dermatitis had slightly increased risk for death during follow-up. While the risk for death from cardiovascular, urogenital, and infectious diseases was slightly elevated among patients with AD, the absolute risk was very low.
| Original language | English |
|---|---|
| Journal | Journal of the American Academy of Dermatology |
| Volume | 78 |
| Issue number | 3 |
| Pages (from-to) | 506-510 |
| ISSN | 0190-9622 |
| DOIs | |
| Publication status | Published - Mar 2018 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Cardiovascular Diseases/mortality
- Case-Control Studies
- Cause of Death
- Denmark/epidemiology
- Dermatitis, Atopic/mortality
- Female
- Female Urogenital Diseases/mortality
- Humans
- Infection/mortality
- Male
- Male Urogenital Diseases/mortality
- Middle Aged
- Proportional Hazards Models
- Registries
