Cause-specific mortality in adults with atopic dermatitis

TY - JOUR

T1 - Cause-specific mortality in adults with atopic dermatitis

AU - Thyssen, Jacob P

AU - Skov, Lone

AU - Egeberg, Alexander

N1 - Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

PY - 2018/3

Y1 - 2018/3

N2 - BACKGROUND: Adult atopic dermatitis (AD) has been associated with several comorbidities, but cause-specific mortality risk is unknown.OBJECTIVE: To examine cause-specific death rates and risk in adults with AD.METHODS: We performed cross-linkage of nationwide health care and cause of death registers. Adult patients with AD were matched with 10 controls per study subject. We calculated incidence rates per 1000 person-years and hazard ratios (HRs) of cause-specific death with 95% confidence intervals (95% CIs) using Cox proportional hazards models.RESULTS: A total of 8686 patients and 86,860 matched controls were studied. The risk for death due to any cause was significantly increased in patients with AD (HR 1.27, 95%CI 1.11-1.45). Significant causes included cardiovascular (HR 1.45; 95% CI 1.07-1.96), infectious (HR 3.71; 95% CI 1.43-9.60), and urogenital diseases (HR 5.51; 95% CI 1.54-19.80). No increased risk for death due to cancer, endocrine, neurologic, psychiatric, respiratory, or gastroenterologic disease was observed.LIMITATIONS: The results might not be generalizable to patients seen exclusively by primary care physicians.CONCLUSION: Adults with atopic dermatitis had slightly increased risk for death during follow-up. While the risk for death from cardiovascular, urogenital, and infectious diseases was slightly elevated among patients with AD, the absolute risk was very low.

AB - BACKGROUND: Adult atopic dermatitis (AD) has been associated with several comorbidities, but cause-specific mortality risk is unknown.OBJECTIVE: To examine cause-specific death rates and risk in adults with AD.METHODS: We performed cross-linkage of nationwide health care and cause of death registers. Adult patients with AD were matched with 10 controls per study subject. We calculated incidence rates per 1000 person-years and hazard ratios (HRs) of cause-specific death with 95% confidence intervals (95% CIs) using Cox proportional hazards models.RESULTS: A total of 8686 patients and 86,860 matched controls were studied. The risk for death due to any cause was significantly increased in patients with AD (HR 1.27, 95%CI 1.11-1.45). Significant causes included cardiovascular (HR 1.45; 95% CI 1.07-1.96), infectious (HR 3.71; 95% CI 1.43-9.60), and urogenital diseases (HR 5.51; 95% CI 1.54-19.80). No increased risk for death due to cancer, endocrine, neurologic, psychiatric, respiratory, or gastroenterologic disease was observed.LIMITATIONS: The results might not be generalizable to patients seen exclusively by primary care physicians.CONCLUSION: Adults with atopic dermatitis had slightly increased risk for death during follow-up. While the risk for death from cardiovascular, urogenital, and infectious diseases was slightly elevated among patients with AD, the absolute risk was very low.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Cardiovascular Diseases/mortality

KW - Case-Control Studies

KW - Cause of Death

KW - Denmark/epidemiology

KW - Dermatitis, Atopic/mortality

KW - Female

KW - Female Urogenital Diseases/mortality

KW - Humans

KW - Infection/mortality

KW - Male

KW - Male Urogenital Diseases/mortality

KW - Middle Aged

KW - Proportional Hazards Models

KW - Registries

U2 - 10.1016/j.jaad.2017.10.032

DO - 10.1016/j.jaad.2017.10.032

M3 - Journal article

C2 - 29102489

SN - 0190-9622

VL - 78

SP - 506

EP - 510

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 3

ER -