Catalytic-independent roles of UTX-1 in C. elegans development

TY - JOUR

T1 - Catalytic-independent roles of UTX-1 in C. elegans development

AU - Vandamme, Julien

AU - Salcini, Anna Elisabetta

PY - 2013/4/1

Y1 - 2013/4/1

N2 - We recently analyzed the functional roles of UTX-1 during development. utx-1 is an essential gene required for the correct embryonic and post-embryonic development of C. elegans, and it displays an H3K27me3 demethylase activity. Rescue experiments demonstrated that the enzymatic activity of UTX-1 is not relevant for its role in development. The phenotypes associated with loss of UTX-1 might, instead, be a result of compromised functions of an UTX-1-containing complex. Here we discuss the possible mechanisms by which UTX-1 contributes to normal development.

AB - We recently analyzed the functional roles of UTX-1 during development. utx-1 is an essential gene required for the correct embryonic and post-embryonic development of C. elegans, and it displays an H3K27me3 demethylase activity. Rescue experiments demonstrated that the enzymatic activity of UTX-1 is not relevant for its role in development. The phenotypes associated with loss of UTX-1 might, instead, be a result of compromised functions of an UTX-1-containing complex. Here we discuss the possible mechanisms by which UTX-1 contributes to normal development.

U2 - 10.4161/worm.22188

DO - 10.4161/worm.22188

M3 - Journal article

C2 - 24058866

SN - 2162-4046

VL - 2

SP - e22188

JO - Worm

JF - Worm

IS - 2

ER -