Carbon monoxide may be an important molecule in migraine and other headaches

Nanna Arngrim; Henrik W Schytz; Mette K Hauge; Messoud Ashina; Jes Olesen

doi:10.1177/0333102414534085

Carbon monoxide may be an important molecule in migraine and other headaches

Nanna Arngrim, Henrik W Schytz, Mette K Hauge, Messoud Ashina, Jes Olesen

Department of Clinical Medicine

12 Citations (Scopus)

Abstract

INTRODUCTION: Carbon monoxide was previously considered to just be a toxic gas. A wealth of recent information has, however, shown that it is also an important endogenously produced signalling molecule involved in multiple biological processes. Endogenously produced carbon monoxide may thus play an important role in nociceptive processing and in regulation of cerebral arterial tone.

DISCUSSION: Carbon monoxide-induced headache shares many characteristics with migraine and other headaches. The mechanisms whereby carbon monoxide causes headache may include hypoxia, nitric oxide signalling and activation of cyclic guanosine monophosphate pathways. Here, we review the literature about carbon monoxide-induced headache and its possible mechanisms.

CONCLUSION: We suggest, for the first time, that carbon monoxide may play an important role in the mechanisms of migraine and other headaches.

Original language	English
Journal	Cephalalgia : an international journal of headache
Volume	34
Issue number	14
Pages (from-to)	1169-1180
Number of pages	12
ISSN	0333-1024
DOIs	https://doi.org/10.1177/0333102414534085
Publication status	Published - Dec 2014

Access to Document

10.1177/0333102414534085

https://journals.sagepub.com/doi/pdf/10.1177/0333102414534085

Cite this

@article{467dd8dd6ec9455a8d2ed7389c8dc6a2,

title = "Carbon monoxide may be an important molecule in migraine and other headaches",

abstract = "INTRODUCTION: Carbon monoxide was previously considered to just be a toxic gas. A wealth of recent information has, however, shown that it is also an important endogenously produced signalling molecule involved in multiple biological processes. Endogenously produced carbon monoxide may thus play an important role in nociceptive processing and in regulation of cerebral arterial tone.DISCUSSION: Carbon monoxide-induced headache shares many characteristics with migraine and other headaches. The mechanisms whereby carbon monoxide causes headache may include hypoxia, nitric oxide signalling and activation of cyclic guanosine monophosphate pathways. Here, we review the literature about carbon monoxide-induced headache and its possible mechanisms.CONCLUSION: We suggest, for the first time, that carbon monoxide may play an important role in the mechanisms of migraine and other headaches.",

author = "Nanna Arngrim and Schytz, {Henrik W} and Hauge, {Mette K} and Messoud Ashina and Jes Olesen",

note = "{\textcopyright} International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.",

year = "2014",

month = dec,

doi = "10.1177/0333102414534085",

language = "English",

volume = "34",

pages = "1169--1180",

journal = "Cephalalgia : an international journal of headache",

issn = "0333-1024",

publisher = "SAGE Publications",

number = "14",

}

TY - JOUR

T1 - Carbon monoxide may be an important molecule in migraine and other headaches

AU - Arngrim, Nanna

AU - Schytz, Henrik W

AU - Hauge, Mette K

AU - Ashina, Messoud

AU - Olesen, Jes

PY - 2014/12

Y1 - 2014/12

N2 - INTRODUCTION: Carbon monoxide was previously considered to just be a toxic gas. A wealth of recent information has, however, shown that it is also an important endogenously produced signalling molecule involved in multiple biological processes. Endogenously produced carbon monoxide may thus play an important role in nociceptive processing and in regulation of cerebral arterial tone.DISCUSSION: Carbon monoxide-induced headache shares many characteristics with migraine and other headaches. The mechanisms whereby carbon monoxide causes headache may include hypoxia, nitric oxide signalling and activation of cyclic guanosine monophosphate pathways. Here, we review the literature about carbon monoxide-induced headache and its possible mechanisms.CONCLUSION: We suggest, for the first time, that carbon monoxide may play an important role in the mechanisms of migraine and other headaches.

AB - INTRODUCTION: Carbon monoxide was previously considered to just be a toxic gas. A wealth of recent information has, however, shown that it is also an important endogenously produced signalling molecule involved in multiple biological processes. Endogenously produced carbon monoxide may thus play an important role in nociceptive processing and in regulation of cerebral arterial tone.DISCUSSION: Carbon monoxide-induced headache shares many characteristics with migraine and other headaches. The mechanisms whereby carbon monoxide causes headache may include hypoxia, nitric oxide signalling and activation of cyclic guanosine monophosphate pathways. Here, we review the literature about carbon monoxide-induced headache and its possible mechanisms.CONCLUSION: We suggest, for the first time, that carbon monoxide may play an important role in the mechanisms of migraine and other headaches.

U2 - 10.1177/0333102414534085

DO - 10.1177/0333102414534085

M3 - Review

C2 - 24816616

SN - 0333-1024

VL - 34

SP - 1169

EP - 1180

JO - Cephalalgia : an international journal of headache

JF - Cephalalgia : an international journal of headache

IS - 14

ER -

Carbon monoxide may be an important molecule in migraine and other headaches

Abstract

Access to Document

Fingerprint

Cite this