Carbon monoxide may be an important molecule in migraine and other headaches

Nanna Arngrim; Henrik W Schytz; Mette K Hauge; Messoud Ashina; Jes Olesen

doi:10.1177/0333102414534085

Carbon monoxide may be an important molecule in migraine and other headaches

Nanna Arngrim, Henrik W Schytz, Mette K Hauge, Messoud Ashina, Jes Olesen

Institut for Klinisk Medicin

12 Citationer (Scopus)

Abstract

INTRODUCTION: Carbon monoxide was previously considered to just be a toxic gas. A wealth of recent information has, however, shown that it is also an important endogenously produced signalling molecule involved in multiple biological processes. Endogenously produced carbon monoxide may thus play an important role in nociceptive processing and in regulation of cerebral arterial tone.

DISCUSSION: Carbon monoxide-induced headache shares many characteristics with migraine and other headaches. The mechanisms whereby carbon monoxide causes headache may include hypoxia, nitric oxide signalling and activation of cyclic guanosine monophosphate pathways. Here, we review the literature about carbon monoxide-induced headache and its possible mechanisms.

CONCLUSION: We suggest, for the first time, that carbon monoxide may play an important role in the mechanisms of migraine and other headaches.

Originalsprog	Engelsk
Tidsskrift	Cephalalgia : an international journal of headache
Vol/bind	34
Udgave nummer	14
Sider (fra-til)	1169-1180
Antal sider	12
ISSN	0333-1024
DOI	https://doi.org/10.1177/0333102414534085
Status	Udgivet - dec. 2014

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10.1177/0333102414534085

https://journals.sagepub.com/doi/pdf/10.1177/0333102414534085

Citationsformater

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T1 - Carbon monoxide may be an important molecule in migraine and other headaches

AU - Arngrim, Nanna

AU - Schytz, Henrik W

AU - Hauge, Mette K

AU - Ashina, Messoud

AU - Olesen, Jes

PY - 2014/12

Y1 - 2014/12

N2 - INTRODUCTION: Carbon monoxide was previously considered to just be a toxic gas. A wealth of recent information has, however, shown that it is also an important endogenously produced signalling molecule involved in multiple biological processes. Endogenously produced carbon monoxide may thus play an important role in nociceptive processing and in regulation of cerebral arterial tone.DISCUSSION: Carbon monoxide-induced headache shares many characteristics with migraine and other headaches. The mechanisms whereby carbon monoxide causes headache may include hypoxia, nitric oxide signalling and activation of cyclic guanosine monophosphate pathways. Here, we review the literature about carbon monoxide-induced headache and its possible mechanisms.CONCLUSION: We suggest, for the first time, that carbon monoxide may play an important role in the mechanisms of migraine and other headaches.

AB - INTRODUCTION: Carbon monoxide was previously considered to just be a toxic gas. A wealth of recent information has, however, shown that it is also an important endogenously produced signalling molecule involved in multiple biological processes. Endogenously produced carbon monoxide may thus play an important role in nociceptive processing and in regulation of cerebral arterial tone.DISCUSSION: Carbon monoxide-induced headache shares many characteristics with migraine and other headaches. The mechanisms whereby carbon monoxide causes headache may include hypoxia, nitric oxide signalling and activation of cyclic guanosine monophosphate pathways. Here, we review the literature about carbon monoxide-induced headache and its possible mechanisms.CONCLUSION: We suggest, for the first time, that carbon monoxide may play an important role in the mechanisms of migraine and other headaches.

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DO - 10.1177/0333102414534085

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EP - 1180

JO - Cephalalgia : an international journal of headache

JF - Cephalalgia : an international journal of headache

IS - 14

ER -

Carbon monoxide may be an important molecule in migraine and other headaches

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