Abstract
INTRODUCTION: For many years, scientists have debated the possibility that an individual "migraine threshold" determines the likelihood with which individuals may express migraine attacks.
DISCUSSION: Recent discoveries provided evidence for both genetic and environmental influences on individual migraine expression. The question is whether any person may express a migraine attack given a sufficiently strong stimulus or provocation. Here, we reviewed and discussed the ability of nitric oxide to induce migraine-like attacks in normal individuals.
CONCLUSION: Experimental data show that normal individuals may develop a migraine-like attack and that the human data point to different ways of further developing existing animal and human models.
Original language | English |
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Journal | Cephalalgia : an international journal of headache |
Volume | 35 |
Issue number | 12 |
Pages (from-to) | 1125-9 |
Number of pages | 5 |
ISSN | 0333-1024 |
DOIs | |
Publication status | Published - 1 Oct 2015 |