Abstract
INTRODUCTION: For many years, scientists have debated the possibility that an individual "migraine threshold" determines the likelihood with which individuals may express migraine attacks.
DISCUSSION: Recent discoveries provided evidence for both genetic and environmental influences on individual migraine expression. The question is whether any person may express a migraine attack given a sufficiently strong stimulus or provocation. Here, we reviewed and discussed the ability of nitric oxide to induce migraine-like attacks in normal individuals.
CONCLUSION: Experimental data show that normal individuals may develop a migraine-like attack and that the human data point to different ways of further developing existing animal and human models.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Cephalalgia : an international journal of headache |
| Vol/bind | 35 |
| Udgave nummer | 12 |
| Sider (fra-til) | 1125-9 |
| Antal sider | 5 |
| ISSN | 0333-1024 |
| DOI | |
| Status | Udgivet - 1 okt. 2015 |