Calcium in Cell-Extracellular Matrix Interactions

Sandeep Gopal; Hinke A B Multhaupt; John R Couchman

doi:10.1007/978-3-030-12457-1_43

Calcium in Cell-Extracellular Matrix Interactions

Sandeep Gopal, Hinke A B Multhaupt, John R Couchman

6 Citations (Scopus)

Abstract

In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.

Original language	English
Book series	Advances in Experimental Medicine and Biology
Volume	1131
Pages (from-to)	1079-1102
Number of pages	24
ISSN	0065-2598
DOIs	https://doi.org/10.1007/978-3-030-12457-1_43
Publication status	Published - 2020

Keywords

Animals
Calcium/metabolism
Cell Movement
Extracellular Matrix/metabolism
Extracellular Matrix Proteins/metabolism

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10.1007/978-3-030-12457-1_43

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title = "Calcium in Cell-Extracellular Matrix Interactions",

abstract = "In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.",

keywords = "Animals, Calcium/metabolism, Cell Movement, Extracellular Matrix/metabolism, Extracellular Matrix Proteins/metabolism",

author = "Sandeep Gopal and Multhaupt, {Hinke A B} and Couchman, {John R}",

year = "2020",

doi = "10.1007/978-3-030-12457-1_43",

language = "English",

volume = "1131",

pages = "1079--1102",

journal = "Advances in Experimental Medicine and Biology",

issn = "0065-2598",

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TY - JOUR

T1 - Calcium in Cell-Extracellular Matrix Interactions

AU - Gopal, Sandeep

AU - Multhaupt, Hinke A B

AU - Couchman, John R

PY - 2020

Y1 - 2020

N2 - In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.

AB - In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.

KW - Animals

KW - Calcium/metabolism

KW - Cell Movement

KW - Extracellular Matrix/metabolism

KW - Extracellular Matrix Proteins/metabolism

U2 - 10.1007/978-3-030-12457-1_43

DO - 10.1007/978-3-030-12457-1_43

M3 - Review

C2 - 31646546

SN - 0065-2598

VL - 1131

SP - 1079

EP - 1102

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

ER -

Calcium in Cell-Extracellular Matrix Interactions

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Keywords

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