TY - JOUR
T1 - Calcium in Cell-Extracellular Matrix Interactions
AU - Gopal, Sandeep
AU - Multhaupt, Hinke A B
AU - Couchman, John R
PY - 2020
Y1 - 2020
N2 - In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.
AB - In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.
KW - Animals
KW - Calcium/metabolism
KW - Cell Movement
KW - Extracellular Matrix/metabolism
KW - Extracellular Matrix Proteins/metabolism
U2 - 10.1007/978-3-030-12457-1_43
DO - 10.1007/978-3-030-12457-1_43
M3 - Review
C2 - 31646546
SN - 0065-2598
VL - 1131
SP - 1079
EP - 1102
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
ER -