Abstract
Vitamin D is an important regulator of calcium homeostasis in the body and it plays an essential role in bone metabolism. 1,25(OH)2D (calcitriol), the active metabolite of vitamin D stimulates intestinal calcium and phosphate absorption, thereby maintaining sufficient concentrations of these ions in the extracellular fluids, necessary for normal mineralization of bone matrix. Furthermore, calcitriol exerts a number of important functions in regulating bone metabolism. Similar to other classical steroid hormones, calcitriol regulates the transcription of a large number of target genes. A large number of recent studies of the mechanisms of genomic actions of calcitriol have been published. The aim of this review is to give a summary of these recent findings. The interaction between calcitriol and the vitamin D receptor as well as receptor structure and function in relation to transcriptional regulation are discussed.
Udgivelsesdato: 1999-Oct-11
Udgivelsesdato: 1999-Oct-11
| Translated title of the contribution | Biological action mechanisms and effects of calcitriol |
|---|---|
| Original language | Danish |
| Journal | Ugeskrift for læger |
| Volume | 161 |
| Issue number | 41 |
| Pages (from-to) | 5669-74 |
| Number of pages | 5 |
| ISSN | 0041-5782 |
| Publication status | Published - 1999 |
| Externally published | Yes |