c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-kappaB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals

Karly C Sourris; Jasmine G Lyons; Maximilian de Courten; Sonia L Dougherty; Darren C Henstridge; Mark E Cooper; Michelle Hage; Anthony Dart; Bronwyn A Kingwell; Josephine M Forbes; Barbora de Courten

doi:10.2337/db08-1725

c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-kappaB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals

Karly C Sourris, Jasmine G Lyons, Maximilian de Courten, Sonia L Dougherty, Darren C Henstridge, Mark E Cooper, Michelle Hage, Anthony Dart, Bronwyn A Kingwell, Josephine M Forbes, Barbora de Courten

26 Citations (Scopus)

Abstract

Chronic low-grade activation of the immune system (CLAIS) predicts type 2 diabetes via a decrease in insulin sensitivity. Our study investigated potential relationships between nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK) pathways-two pathways proposed as the link between CLAIS and insulin resistance.

Original language	English
Journal	Diabetes
Volume	58
Issue number	6
Pages (from-to)	1259-65
Number of pages	7
ISSN	0012-1797
DOIs	https://doi.org/10.2337/db08-1725
Publication status	Published - 1 Jun 2009

Keywords

Adolescent
Adult
Biopsy
Blood Glucose
Body Mass Index
Cell Nucleus
DNA Primers
Female
Humans
Insulin Resistance
JNK Mitogen-Activated Protein Kinases
Leukocyte Count
Leukocytes, Mononuclear
Male
Middle Aged
Mitogen-Activated Protein Kinase 8
Mitogen-Activated Protein Kinase 9
Muscle, Skeletal
NF-kappa B
Reference Values
Reverse Transcriptase Polymerase Chain Reaction
Subcutaneous Fat
Waist-Hip Ratio
Young Adult
eIF-2 Kinase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Sourris, K. C., Lyons, J. G., de Courten, M., Dougherty, S. L., Henstridge, D. C., Cooper, M. E., Hage, M., Dart, A., Kingwell, B. A., Forbes, J. M., & de Courten, B. (2009). c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-kappaB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals. Diabetes, 58(6), 1259-65. https://doi.org/10.2337/db08-1725

c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-kappaB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals. / Sourris, Karly C; Lyons, Jasmine G; de Courten, Maximilian et al.

In: Diabetes, Vol. 58, No. 6, 01.06.2009, p. 1259-65.

Research output: Contribution to journal › Journal article › Research › peer-review

Sourris, KC, Lyons, JG, de Courten, M, Dougherty, SL, Henstridge, DC, Cooper, ME, Hage, M, Dart, A, Kingwell, BA, Forbes, JM & de Courten, B 2009, 'c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-kappaB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals', Diabetes, vol. 58, no. 6, pp. 1259-65. https://doi.org/10.2337/db08-1725

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abstract = "Chronic low-grade activation of the immune system (CLAIS) predicts type 2 diabetes via a decrease in insulin sensitivity. Our study investigated potential relationships between nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK) pathways-two pathways proposed as the link between CLAIS and insulin resistance.",

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