c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-kappaB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals

Karly C Sourris, Jasmine G Lyons, Maximilian de Courten, Sonia L Dougherty, Darren C Henstridge, Mark E Cooper, Michelle Hage, Anthony Dart, Bronwyn A Kingwell, Josephine M Forbes, Barbora de Courten

26 Citationer (Scopus)

Abstract

Chronic low-grade activation of the immune system (CLAIS) predicts type 2 diabetes via a decrease in insulin sensitivity. Our study investigated potential relationships between nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK) pathways-two pathways proposed as the link between CLAIS and insulin resistance.
OriginalsprogEngelsk
TidsskriftDiabetes
Vol/bind58
Udgave nummer6
Sider (fra-til)1259-65
Antal sider7
ISSN0012-1797
DOI
StatusUdgivet - 1 jun. 2009

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