Building authentic midbrain dopaminergic neurons from stem CEllS - Lessons from development

Agnete Kirkeby; Malin Parmar

doi:10.2478/s13380-012-0041-x

Building authentic midbrain dopaminergic neurons from stem CEllS - Lessons from development

Agnete Kirkeby^*, Malin Parmar

^*Corresponding author for this work

Laboratory

6 Citations (Scopus)

Abstract

The challenge with controlling the differentiation of human pluripotent cells to generate functional dopaminergic neurons for the treatment of Parkinson's disease has undergone significant progress in recent years. Here, we summarize the differences between newer and older protocols for generating midbrain dopaminergic neurons from human pluripotent stem cells, and we highlight the importance of following developmental pathways during differentiation. The field has now developed to a point where it is timely to take human pluripotent stem cells one step closer to clinical use, and cell criteria to be fulfilled for such developments are outlined in this review.

Original language	English
Journal	Translational Neuroscience
Volume	3
Issue number	4
Pages (from-to)	314-319
Number of pages	6
ISSN	2081-3856
DOIs	https://doi.org/10.2478/s13380-012-0041-x
Publication status	Published - 1 Dec 2012

Keywords

Development
Differentiation
Dopaminergic neurons
Stem cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2478/s13380-012-0041-x

http://www.degruyter.com/downloadpdf/j/tnsci.2012.3.issue-4/s13380-012-0041-x/s13380-012-0041-x.xmlLicence: CC BY-NC-ND

Cite this

@article{2d02269b09364d098e29448492e414c9,

title = "Building authentic midbrain dopaminergic neurons from stem CEllS - Lessons from development",

abstract = "The challenge with controlling the differentiation of human pluripotent cells to generate functional dopaminergic neurons for the treatment of Parkinson's disease has undergone significant progress in recent years. Here, we summarize the differences between newer and older protocols for generating midbrain dopaminergic neurons from human pluripotent stem cells, and we highlight the importance of following developmental pathways during differentiation. The field has now developed to a point where it is timely to take human pluripotent stem cells one step closer to clinical use, and cell criteria to be fulfilled for such developments are outlined in this review.",

keywords = "Development, Differentiation, Dopaminergic neurons, Stem cells",

author = "Agnete Kirkeby and Malin Parmar",

year = "2012",

month = dec,

day = "1",

doi = "10.2478/s13380-012-0041-x",

language = "English",

volume = "3",

pages = "314--319",

journal = "Translational Neuroscience",

issn = "2081-3856",

publisher = "De Gruyter Open Ltd.",

number = "4",

}

TY - JOUR

T1 - Building authentic midbrain dopaminergic neurons from stem CEllS - Lessons from development

AU - Kirkeby, Agnete

AU - Parmar, Malin

PY - 2012/12/1

Y1 - 2012/12/1

N2 - The challenge with controlling the differentiation of human pluripotent cells to generate functional dopaminergic neurons for the treatment of Parkinson's disease has undergone significant progress in recent years. Here, we summarize the differences between newer and older protocols for generating midbrain dopaminergic neurons from human pluripotent stem cells, and we highlight the importance of following developmental pathways during differentiation. The field has now developed to a point where it is timely to take human pluripotent stem cells one step closer to clinical use, and cell criteria to be fulfilled for such developments are outlined in this review.

AB - The challenge with controlling the differentiation of human pluripotent cells to generate functional dopaminergic neurons for the treatment of Parkinson's disease has undergone significant progress in recent years. Here, we summarize the differences between newer and older protocols for generating midbrain dopaminergic neurons from human pluripotent stem cells, and we highlight the importance of following developmental pathways during differentiation. The field has now developed to a point where it is timely to take human pluripotent stem cells one step closer to clinical use, and cell criteria to be fulfilled for such developments are outlined in this review.

KW - Development

KW - Differentiation

KW - Dopaminergic neurons

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=84871421869&partnerID=8YFLogxK

U2 - 10.2478/s13380-012-0041-x

DO - 10.2478/s13380-012-0041-x

M3 - Review

AN - SCOPUS:84871421869

SN - 2081-3856

VL - 3

SP - 314

EP - 319

JO - Translational Neuroscience

JF - Translational Neuroscience

IS - 4

ER -

Building authentic midbrain dopaminergic neurons from stem CEllS - Lessons from development

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this