Breed differences in natriuretic peptides in healthy dogs

K. Sjöstrand; G. Wess; I. Ljungvall; J. Häggström; A.-C. Merveille; M. Wiberg; V. Gouni; Jakob Willesen; S. Hanås; A.-S. Lequarré; L. Mejer Sørensen; J. Wolf; L Tiret; M. Kierczak; S. Forsberg; K. McEntee; G. Battaille; E. Seppälä; K. Lindblad-Toh; M. Georges; Hannes Lohi; V. Chetboul; Merete Fredholm; K. Höglund

doi:10.1111/jvim.12310

Breed differences in natriuretic peptides in healthy dogs

K. Sjöstrand, G. Wess, I. Ljungvall, J. Häggström, A.-C. Merveille, M. Wiberg, V. Gouni, Jakob Willesen, S. Hanås, A.-S. Lequarré, L. Mejer Sørensen, J. Wolf, L Tiret, M. Kierczak, S. Forsberg, K. McEntee, G. Battaille, E. Seppälä, K. Lindblad-Toh, M. GeorgesHannes Lohi, V. Chetboul, Merete Fredholm, K. Höglund

32 Citations (Scopus)

Abstract

Background: Measurement of plasma concentration of natriuretic peptides (NPs) is suggested to be of value in diagnosis of cardiac disease in dogs, but many factors other than cardiac status may influence their concentrations. Dog breed potentially is 1 such factor. Objective: To investigate breed variation in plasma concentrations of pro-atrial natriuretic peptide 31-67 (proANP 31-67) and N-terminal B-type natriuretic peptide (NT-proBNP) in healthy dogs. Animals: 535 healthy, privately owned dogs of 9 breeds were examined at 5 centers as part of the European Union (EU) LUPA project. Methods: Absence of cardiovascular disease or other clinically relevant organ-related or systemic disease was ensured by thorough clinical investigation. Plasma concentrations of proANP 31-67 and NT-proBNP were measured by commercially available ELISA assays. Results: Overall significant breed differences were found in proANP 31-67 (P < .0001) and NT-proBNP (P < .0001) concentrations. Pair-wise comparisons between breeds differed in approximately 50% of comparisons for proANP 31-67 as well as NT-proBNP concentrations, both when including all centers and within each center. Interquartile range was large for many breeds, especially for NT-proBNP. Among included breeds, Labrador Retrievers and Newfoundlands had highest median NT-proBNP concentrations with concentrations 3 times as high as those of Dachshunds. German Shepherds and Cavalier King Charles Spaniels had the highest median proANP 31-67 concentrations, twice the median concentration in Doberman Pinschers. Conclusions and Clinical Importance: Considerable interbreed variation in plasma NP concentrations was found in healthy dogs. Intrabreed variation was large in several breeds, especially for NT-proBNP. Additional studies are needed to establish breed-specific reference ranges.

Original language	English
Journal	Journal of Veterinary Internal Medicine
Volume	28
Issue number	2
Pages (from-to)	451-457
Number of pages	7
ISSN	0891-6640
DOIs	https://doi.org/10.1111/jvim.12310
Publication status	Published - Mar 2014

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10.1111/jvim.12310

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Sjöstrand, K., Wess, G., Ljungvall, I., Häggström, J., Merveille, A.-C., Wiberg, M., Gouni, V., Willesen, J., Hanås, S., Lequarré, A.-S., Sørensen, L. M., Wolf, J., Tiret, L., Kierczak, M., Forsberg, S., McEntee, K., Battaille, G., Seppälä, E., Lindblad-Toh, K., ... Höglund, K. (2014). Breed differences in natriuretic peptides in healthy dogs. Journal of Veterinary Internal Medicine, 28(2), 451-457. https://doi.org/10.1111/jvim.12310

Sjöstrand, K, Wess, G, Ljungvall, I, Häggström, J, Merveille, A-C, Wiberg, M, Gouni, V, Willesen, J, Hanås, S, Lequarré, A-S, Sørensen, LM, Wolf, J, Tiret, L, Kierczak, M, Forsberg, S, McEntee, K, Battaille, G, Seppälä, E, Lindblad-Toh, K, Georges, M, Lohi, H, Chetboul, V, Fredholm, M & Höglund, K 2014, 'Breed differences in natriuretic peptides in healthy dogs', Journal of Veterinary Internal Medicine, vol. 28, no. 2, pp. 451-457. https://doi.org/10.1111/jvim.12310

@article{0ffda028d09d4fdf9a79522b790cd43d,

title = "Breed differences in natriuretic peptides in healthy dogs",

abstract = "Background: Measurement of plasma concentration of natriuretic peptides (NPs) is suggested to be of value in diagnosis of cardiac disease in dogs, but many factors other than cardiac status may influence their concentrations. Dog breed potentially is 1 such factor. Objective: To investigate breed variation in plasma concentrations of pro-atrial natriuretic peptide 31-67 (proANP 31-67) and N-terminal B-type natriuretic peptide (NT-proBNP) in healthy dogs. Animals: 535 healthy, privately owned dogs of 9 breeds were examined at 5 centers as part of the European Union (EU) LUPA project. Methods: Absence of cardiovascular disease or other clinically relevant organ-related or systemic disease was ensured by thorough clinical investigation. Plasma concentrations of proANP 31-67 and NT-proBNP were measured by commercially available ELISA assays. Results: Overall significant breed differences were found in proANP 31-67 (P < .0001) and NT-proBNP (P < .0001) concentrations. Pair-wise comparisons between breeds differed in approximately 50% of comparisons for proANP 31-67 as well as NT-proBNP concentrations, both when including all centers and within each center. Interquartile range was large for many breeds, especially for NT-proBNP. Among included breeds, Labrador Retrievers and Newfoundlands had highest median NT-proBNP concentrations with concentrations 3 times as high as those of Dachshunds. German Shepherds and Cavalier King Charles Spaniels had the highest median proANP 31-67 concentrations, twice the median concentration in Doberman Pinschers. Conclusions and Clinical Importance: Considerable interbreed variation in plasma NP concentrations was found in healthy dogs. Intrabreed variation was large in several breeds, especially for NT-proBNP. Additional studies are needed to establish breed-specific reference ranges.",

author = "K. Sj{\"o}strand and G. Wess and I. Ljungvall and J. H{\"a}ggstr{\"o}m and A.-C. Merveille and M. Wiberg and V. Gouni and Jakob Willesen and S. Han{\aa}s and A.-S. Lequarr{\'e} and S{\o}rensen, {L. Mejer} and J. Wolf and L Tiret and M. Kierczak and S. Forsberg and K. McEntee and G. Battaille and E. Sepp{\"a}l{\"a} and K. Lindblad-Toh and M. Georges and Hannes Lohi and V. Chetboul and Merete Fredholm and K. H{\"o}glund",

note = "Copyright {\textcopyright} 2014 by the American College of Veterinary Internal Medicine.",

year = "2014",

month = mar,

doi = "10.1111/jvim.12310",

language = "English",

volume = "28",

pages = "451--457",

journal = "Journal of Veterinary Internal Medicine",

issn = "0891-6640",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Breed differences in natriuretic peptides in healthy dogs

AU - Sjöstrand, K.

AU - Wess, G.

AU - Ljungvall, I.

AU - Häggström, J.

AU - Merveille, A.-C.

AU - Wiberg, M.

AU - Gouni, V.

AU - Willesen, Jakob

AU - Hanås, S.

AU - Lequarré, A.-S.

AU - Sørensen, L. Mejer

AU - Wolf, J.

AU - Tiret, L

AU - Kierczak, M.

AU - Forsberg, S.

AU - McEntee, K.

AU - Battaille, G.

AU - Seppälä, E.

AU - Lindblad-Toh, K.

AU - Georges, M.

AU - Lohi, Hannes

AU - Chetboul, V.

AU - Fredholm, Merete

AU - Höglund, K.

PY - 2014/3

Y1 - 2014/3

N2 - Background: Measurement of plasma concentration of natriuretic peptides (NPs) is suggested to be of value in diagnosis of cardiac disease in dogs, but many factors other than cardiac status may influence their concentrations. Dog breed potentially is 1 such factor. Objective: To investigate breed variation in plasma concentrations of pro-atrial natriuretic peptide 31-67 (proANP 31-67) and N-terminal B-type natriuretic peptide (NT-proBNP) in healthy dogs. Animals: 535 healthy, privately owned dogs of 9 breeds were examined at 5 centers as part of the European Union (EU) LUPA project. Methods: Absence of cardiovascular disease or other clinically relevant organ-related or systemic disease was ensured by thorough clinical investigation. Plasma concentrations of proANP 31-67 and NT-proBNP were measured by commercially available ELISA assays. Results: Overall significant breed differences were found in proANP 31-67 (P < .0001) and NT-proBNP (P < .0001) concentrations. Pair-wise comparisons between breeds differed in approximately 50% of comparisons for proANP 31-67 as well as NT-proBNP concentrations, both when including all centers and within each center. Interquartile range was large for many breeds, especially for NT-proBNP. Among included breeds, Labrador Retrievers and Newfoundlands had highest median NT-proBNP concentrations with concentrations 3 times as high as those of Dachshunds. German Shepherds and Cavalier King Charles Spaniels had the highest median proANP 31-67 concentrations, twice the median concentration in Doberman Pinschers. Conclusions and Clinical Importance: Considerable interbreed variation in plasma NP concentrations was found in healthy dogs. Intrabreed variation was large in several breeds, especially for NT-proBNP. Additional studies are needed to establish breed-specific reference ranges.

AB - Background: Measurement of plasma concentration of natriuretic peptides (NPs) is suggested to be of value in diagnosis of cardiac disease in dogs, but many factors other than cardiac status may influence their concentrations. Dog breed potentially is 1 such factor. Objective: To investigate breed variation in plasma concentrations of pro-atrial natriuretic peptide 31-67 (proANP 31-67) and N-terminal B-type natriuretic peptide (NT-proBNP) in healthy dogs. Animals: 535 healthy, privately owned dogs of 9 breeds were examined at 5 centers as part of the European Union (EU) LUPA project. Methods: Absence of cardiovascular disease or other clinically relevant organ-related or systemic disease was ensured by thorough clinical investigation. Plasma concentrations of proANP 31-67 and NT-proBNP were measured by commercially available ELISA assays. Results: Overall significant breed differences were found in proANP 31-67 (P < .0001) and NT-proBNP (P < .0001) concentrations. Pair-wise comparisons between breeds differed in approximately 50% of comparisons for proANP 31-67 as well as NT-proBNP concentrations, both when including all centers and within each center. Interquartile range was large for many breeds, especially for NT-proBNP. Among included breeds, Labrador Retrievers and Newfoundlands had highest median NT-proBNP concentrations with concentrations 3 times as high as those of Dachshunds. German Shepherds and Cavalier King Charles Spaniels had the highest median proANP 31-67 concentrations, twice the median concentration in Doberman Pinschers. Conclusions and Clinical Importance: Considerable interbreed variation in plasma NP concentrations was found in healthy dogs. Intrabreed variation was large in several breeds, especially for NT-proBNP. Additional studies are needed to establish breed-specific reference ranges.

U2 - 10.1111/jvim.12310

DO - 10.1111/jvim.12310

M3 - Journal article

C2 - 24495256

SN - 0891-6640

VL - 28

SP - 451

EP - 457

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

IS - 2

ER -

Breed differences in natriuretic peptides in healthy dogs

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