Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans

Peter Rasmussen; Nikolai Nordsborg; Sarah Taudorf; Henrik Sørensen; Ronan M G Berg; Robert A Jacobs; Damian M Bailey; Niels V Olsen; Niels H Secher; Kirsten Møller; Carsten Lundby

doi:10.1096/fj.11-191692

Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans

Peter Rasmussen, Nikolai Nordsborg, Sarah Taudorf, Henrik Sørensen, Ronan M G Berg, Robert A Jacobs, Damian M Bailey, Niels V Olsen, Niels H Secher, Kirsten Møller, Carsten Lundby

11 Citations (Scopus)

Abstract

Erythropoietin (EPO) preserves arterial oxygen content by controlling red blood cell and plasma volumes. Synthesis of EPO was long thought to relate inversely to renal oxygenation, but in knockout mice, brain and skin have been identified as essential for the acute hypoxic EPO response. Whether these findings apply to humans remains unknown. We exposed healthy young subjects to hypoxia (equivalent to 3800 m) and measured EPO in arterial and jugular venous plasma and in cerebrospinal fluid. To examine the role of the skin for EPO production during hypoxia, subjects were exposed to 8 h of hypobaric hypoxia with or without breathing oxygen-enriched air to ensure systemic normoxemia. With 9 h of hypoxia, arterial EPO increased (from 6.0±2.2 to 22.0±6.0 mU/ml, n=11, P

Original language	English
Journal	F A S E B Journal
Volume	26
Issue number	5
Pages (from-to)	1831-1834
Number of pages	4
ISSN	0892-6638
DOIs	https://doi.org/10.1096/fj.11-191692
Publication status	Published - May 2012

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title = "Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans",

abstract = "Erythropoietin (EPO) preserves arterial oxygen content by controlling red blood cell and plasma volumes. Synthesis of EPO was long thought to relate inversely to renal oxygenation, but in knockout mice, brain and skin have been identified as essential for the acute hypoxic EPO response. Whether these findings apply to humans remains unknown. We exposed healthy young subjects to hypoxia (equivalent to 3800 m) and measured EPO in arterial and jugular venous plasma and in cerebrospinal fluid. To examine the role of the skin for EPO production during hypoxia, subjects were exposed to 8 h of hypobaric hypoxia with or without breathing oxygen-enriched air to ensure systemic normoxemia. With 9 h of hypoxia, arterial EPO increased (from 6.0±2.2 to 22.0±6.0 mU/ml, n=11, P",

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T1 - Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans

AU - Rasmussen, Peter

AU - Nordsborg, Nikolai

AU - Taudorf, Sarah

AU - Sørensen, Henrik

AU - Berg, Ronan M G

AU - Jacobs, Robert A

AU - Bailey, Damian M

AU - Olsen, Niels V

AU - Secher, Niels H

AU - Møller, Kirsten

AU - Lundby, Carsten

N1 - CURIS 2012 5200 024

PY - 2012/5

Y1 - 2012/5

N2 - Erythropoietin (EPO) preserves arterial oxygen content by controlling red blood cell and plasma volumes. Synthesis of EPO was long thought to relate inversely to renal oxygenation, but in knockout mice, brain and skin have been identified as essential for the acute hypoxic EPO response. Whether these findings apply to humans remains unknown. We exposed healthy young subjects to hypoxia (equivalent to 3800 m) and measured EPO in arterial and jugular venous plasma and in cerebrospinal fluid. To examine the role of the skin for EPO production during hypoxia, subjects were exposed to 8 h of hypobaric hypoxia with or without breathing oxygen-enriched air to ensure systemic normoxemia. With 9 h of hypoxia, arterial EPO increased (from 6.0±2.2 to 22.0±6.0 mU/ml, n=11, P

AB - Erythropoietin (EPO) preserves arterial oxygen content by controlling red blood cell and plasma volumes. Synthesis of EPO was long thought to relate inversely to renal oxygenation, but in knockout mice, brain and skin have been identified as essential for the acute hypoxic EPO response. Whether these findings apply to humans remains unknown. We exposed healthy young subjects to hypoxia (equivalent to 3800 m) and measured EPO in arterial and jugular venous plasma and in cerebrospinal fluid. To examine the role of the skin for EPO production during hypoxia, subjects were exposed to 8 h of hypobaric hypoxia with or without breathing oxygen-enriched air to ensure systemic normoxemia. With 9 h of hypoxia, arterial EPO increased (from 6.0±2.2 to 22.0±6.0 mU/ml, n=11, P

U2 - 10.1096/fj.11-191692

DO - 10.1096/fj.11-191692

M3 - Journal article

C2 - 22321729

SN - 0892-6638

VL - 26

SP - 1831

EP - 1834

JO - F A S E B Journal

JF - F A S E B Journal

IS - 5

ER -

Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans

Abstract

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