Blood-brain distribution of morphine-6-glucuronide in sheep

H H Villesen; D J R Foster; R N Upton; Lona Louring Christrup; A A Somogyi; Angel Ricardo Martinez; C Grant

doi:10.1038/sj.bjp.0706916

Blood-brain distribution of morphine-6-glucuronide in sheep

H H Villesen, D J R Foster, R N Upton, Lona Louring Christrup, A A Somogyi, Angel Ricardo Martinez, C Grant

2 Citations (Scopus)

Abstract

At present there are few data regarding the rate and extent of brain-blood partitioning of the opioid active metabolite of morphine, morphine-6-glucuronide (M6G). In this study the cerebral kinetics of M6G were determined, after a short-term intravenous infusion, in chronically instrumented conscious sheep.

Original language	English
Journal	British Journal of Pharmacology
Volume	149
Issue number	6
Pages (from-to)	754-60
Number of pages	7
ISSN	0007-1188
DOIs	https://doi.org/10.1038/sj.bjp.0706916
Publication status	Published - Nov 2006

Keywords

Animals
Blood-Brain Barrier
Chromatography, High Pressure Liquid
Morphine Derivatives
Sheep

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10.1038/sj.bjp.0706916

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014650/

Cite this

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title = "Blood-brain distribution of morphine-6-glucuronide in sheep",

abstract = "At present there are few data regarding the rate and extent of brain-blood partitioning of the opioid active metabolite of morphine, morphine-6-glucuronide (M6G). In this study the cerebral kinetics of M6G were determined, after a short-term intravenous infusion, in chronically instrumented conscious sheep.",

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author = "Villesen, {H H} and Foster, {D J R} and Upton, {R N} and Christrup, {Lona Louring} and Somogyi, {A A} and Martinez, {Angel Ricardo} and C Grant",

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T1 - Blood-brain distribution of morphine-6-glucuronide in sheep

AU - Villesen, H H

AU - Foster, D J R

AU - Upton, R N

AU - Christrup, Lona Louring

AU - Somogyi, A A

AU - Martinez, Angel Ricardo

AU - Grant, C

PY - 2006/11

Y1 - 2006/11

N2 - At present there are few data regarding the rate and extent of brain-blood partitioning of the opioid active metabolite of morphine, morphine-6-glucuronide (M6G). In this study the cerebral kinetics of M6G were determined, after a short-term intravenous infusion, in chronically instrumented conscious sheep.

AB - At present there are few data regarding the rate and extent of brain-blood partitioning of the opioid active metabolite of morphine, morphine-6-glucuronide (M6G). In this study the cerebral kinetics of M6G were determined, after a short-term intravenous infusion, in chronically instrumented conscious sheep.

KW - Animals

KW - Blood-Brain Barrier

KW - Chromatography, High Pressure Liquid

KW - Morphine Derivatives

KW - Sheep

U2 - 10.1038/sj.bjp.0706916

DO - 10.1038/sj.bjp.0706916

M3 - Journal article

C2 - 17016501

SN - 0007-1188

VL - 149

SP - 754

EP - 760

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 6

ER -

Blood-brain distribution of morphine-6-glucuronide in sheep

Abstract

Keywords

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