BK channel activators and their therapeutic perspectives

Bo Hjorth Bentzen; Søren-Peter Olesen; Lars C B Rønn; Morten Grunnet

doi:10.3389/fphys.2014.00389

BK channel activators and their therapeutic perspectives

Bo Hjorth Bentzen, Søren-Peter Olesen, Lars C B Rønn, Morten Grunnet

Physiology of circulation, kidney and lung

94 Citations (Scopus)

63 Downloads (Pure)

Abstract

The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important negative feedback system linking increases in intracellular calcium to outward hyperpolarizing potassium currents. Consequently, the channel has many important physiological roles including regulation of smooth muscle tone, neurotransmitter release and neuronal excitability. Additionally, cardioprotective roles have been revealed in recent years. After a short introduction to the structure, function and regulation of BK channels, we review the small organic molecules activating BK channels and how these tool compounds have helped delineate the roles of BK channels in health and disease.

Original language	English
Journal	Frontiers in Physiology
Volume	5
Pages (from-to)	1-12
Number of pages	12
ISSN	1664-042X
DOIs	https://doi.org/10.3389/fphys.2014.00389
Publication status	Published - 2014

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AU - Bentzen, Bo Hjorth

AU - Olesen, Søren-Peter

AU - Rønn, Lars C B

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AB - The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important negative feedback system linking increases in intracellular calcium to outward hyperpolarizing potassium currents. Consequently, the channel has many important physiological roles including regulation of smooth muscle tone, neurotransmitter release and neuronal excitability. Additionally, cardioprotective roles have been revealed in recent years. After a short introduction to the structure, function and regulation of BK channels, we review the small organic molecules activating BK channels and how these tool compounds have helped delineate the roles of BK channels in health and disease.

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JO - Frontiers in Physiology

JF - Frontiers in Physiology

ER -

BK channel activators and their therapeutic perspectives

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