BK channel activators and their therapeutic perspectives

Bo Hjorth Bentzen; Søren-Peter Olesen; Lars C B Rønn; Morten Grunnet

doi:10.3389/fphys.2014.00389

BK channel activators and their therapeutic perspectives

Bo Hjorth Bentzen, Søren-Peter Olesen, Lars C B Rønn, Morten Grunnet

Physiology of circulation, kidney and lung

94 Citationer (Scopus)

63 Downloads (Pure)

Abstract

The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important negative feedback system linking increases in intracellular calcium to outward hyperpolarizing potassium currents. Consequently, the channel has many important physiological roles including regulation of smooth muscle tone, neurotransmitter release and neuronal excitability. Additionally, cardioprotective roles have been revealed in recent years. After a short introduction to the structure, function and regulation of BK channels, we review the small organic molecules activating BK channels and how these tool compounds have helped delineate the roles of BK channels in health and disease.

Originalsprog	Engelsk
Tidsskrift	Frontiers in Physiology
Vol/bind	5
Sider (fra-til)	1-12
Antal sider	12
ISSN	1664-042X
DOI	https://doi.org/10.3389/fphys.2014.00389
Status	Udgivet - 2014

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10.3389/fphys.2014.00389Licens: CC BY

fphys-05-00389Forlagets udgivne version, 494 KBLicens: CC BY

Citationsformater

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AU - Bentzen, Bo Hjorth

AU - Olesen, Søren-Peter

AU - Rønn, Lars C B

AU - Grunnet, Morten

PY - 2014

Y1 - 2014

N2 - The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important negative feedback system linking increases in intracellular calcium to outward hyperpolarizing potassium currents. Consequently, the channel has many important physiological roles including regulation of smooth muscle tone, neurotransmitter release and neuronal excitability. Additionally, cardioprotective roles have been revealed in recent years. After a short introduction to the structure, function and regulation of BK channels, we review the small organic molecules activating BK channels and how these tool compounds have helped delineate the roles of BK channels in health and disease.

AB - The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important negative feedback system linking increases in intracellular calcium to outward hyperpolarizing potassium currents. Consequently, the channel has many important physiological roles including regulation of smooth muscle tone, neurotransmitter release and neuronal excitability. Additionally, cardioprotective roles have been revealed in recent years. After a short introduction to the structure, function and regulation of BK channels, we review the small organic molecules activating BK channels and how these tool compounds have helped delineate the roles of BK channels in health and disease.

U2 - 10.3389/fphys.2014.00389

DO - 10.3389/fphys.2014.00389

M3 - Journal article

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SN - 1664-042X

VL - 5

SP - 1

EP - 12

JO - Frontiers in Physiology

JF - Frontiers in Physiology

ER -

BK channel activators and their therapeutic perspectives

Abstract

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