Biofilms and host response - helpful or harmful

Claus Moser; Hannah Trøstrup Pedersen; Christian Johann Lerche; Mette Kolpen; Laura Line; Kim Thomsen; Niels Høiby; Peter Østrup Jensen

doi:10.1111/apm.12674

Biofilms and host response - helpful or harmful

Claus Moser, Hannah Trøstrup Pedersen, Christian Johann Lerche, Mette Kolpen, Laura Line, Kim Thomsen, Niels Høiby, Peter Østrup Jensen

47 Citations (Scopus)

Abstract

Biofilm infections are one of the modern medical world's greatest challenges. Probably, all non-obligate intracellular bacteria and fungi can establish biofilms. In addition, there are numerous biofilm-related infections, both foreign body-related and non-foreign body-related. Although biofilm infections can present in numerous ways, one common feature is involvement of the host response with significant impact on the course. A special characteristic is the synergy of the innate and the acquired immune responses for the induced pathology. Here, we review the impact of the host response for the course of biofilm infections, with special focus on cystic fibrosis, chronic wounds and infective endocarditis.

Original language	English
Journal	A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
Volume	125
Issue number	4
Pages (from-to)	320-338
Number of pages	19
ISSN	0903-4641
DOIs	https://doi.org/10.1111/apm.12674
Publication status	Published - Apr 2017

Keywords

Biofilms
Cystic Fibrosis
Host-Pathogen Interactions
Humans
Immunity
Pseudomonas Infections
Pseudomonas aeruginosa
Journal Article
Review

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Cite this

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title = "Biofilms and host response - helpful or harmful",

abstract = "Biofilm infections are one of the modern medical world's greatest challenges. Probably, all non-obligate intracellular bacteria and fungi can establish biofilms. In addition, there are numerous biofilm-related infections, both foreign body-related and non-foreign body-related. Although biofilm infections can present in numerous ways, one common feature is involvement of the host response with significant impact on the course. A special characteristic is the synergy of the innate and the acquired immune responses for the induced pathology. Here, we review the impact of the host response for the course of biofilm infections, with special focus on cystic fibrosis, chronic wounds and infective endocarditis.",

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AU - Moser, Claus

AU - Pedersen, Hannah Trøstrup

AU - Lerche, Christian Johann

AU - Kolpen, Mette

AU - Line, Laura

AU - Thomsen, Kim

AU - Høiby, Niels

AU - Jensen, Peter Østrup

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KW - Cystic Fibrosis

KW - Host-Pathogen Interactions

KW - Humans

KW - Immunity

KW - Pseudomonas Infections

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Biofilms and host response - helpful or harmful

Abstract

Keywords

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