Biofilms and host response - helpful or harmful

Claus Moser, Hannah Trøstrup Pedersen, Christian Johann Lerche, Mette Kolpen, Laura Line, Kim Thomsen, Niels Høiby, Peter Østrup Jensen

    47 Citations (Scopus)

    Abstract

    Biofilm infections are one of the modern medical world's greatest challenges. Probably, all non-obligate intracellular bacteria and fungi can establish biofilms. In addition, there are numerous biofilm-related infections, both foreign body-related and non-foreign body-related. Although biofilm infections can present in numerous ways, one common feature is involvement of the host response with significant impact on the course. A special characteristic is the synergy of the innate and the acquired immune responses for the induced pathology. Here, we review the impact of the host response for the course of biofilm infections, with special focus on cystic fibrosis, chronic wounds and infective endocarditis.

    Original languageEnglish
    JournalA P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
    Volume125
    Issue number4
    Pages (from-to)320-338
    Number of pages19
    ISSN0903-4641
    DOIs
    Publication statusPublished - Apr 2017

    Keywords

    • Biofilms
    • Cystic Fibrosis
    • Host-Pathogen Interactions
    • Humans
    • Immunity
    • Pseudomonas Infections
    • Pseudomonas aeruginosa
    • Journal Article
    • Review

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