Biofilms and host response - helpful or harmful

Claus Moser; Hannah Trøstrup Pedersen; Christian Johann Lerche; Mette Kolpen; Laura Line; Kim Thomsen; Niels Høiby; Peter Østrup Jensen

doi:10.1111/apm.12674

Biofilms and host response - helpful or harmful

Claus Moser, Hannah Trøstrup Pedersen, Christian Johann Lerche, Mette Kolpen, Laura Line, Kim Thomsen, Niels Høiby, Peter Østrup Jensen

47 Citationer (Scopus)

Abstract

Biofilm infections are one of the modern medical world's greatest challenges. Probably, all non-obligate intracellular bacteria and fungi can establish biofilms. In addition, there are numerous biofilm-related infections, both foreign body-related and non-foreign body-related. Although biofilm infections can present in numerous ways, one common feature is involvement of the host response with significant impact on the course. A special characteristic is the synergy of the innate and the acquired immune responses for the induced pathology. Here, we review the impact of the host response for the course of biofilm infections, with special focus on cystic fibrosis, chronic wounds and infective endocarditis.

Originalsprog	Engelsk
Tidsskrift	A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
Vol/bind	125
Udgave nummer	4
Sider (fra-til)	320-338
Antal sider	19
ISSN	0903-4641
DOI	https://doi.org/10.1111/apm.12674
Status	Udgivet - apr. 2017

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10.1111/apm.12674

apm.12674Forlagets udgivne version, 617 KB

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apm.12674

Citationsformater

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AU - Moser, Claus

AU - Pedersen, Hannah Trøstrup

AU - Lerche, Christian Johann

AU - Kolpen, Mette

AU - Line, Laura

AU - Thomsen, Kim

AU - Høiby, Niels

AU - Jensen, Peter Østrup

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N2 - Biofilm infections are one of the modern medical world's greatest challenges. Probably, all non-obligate intracellular bacteria and fungi can establish biofilms. In addition, there are numerous biofilm-related infections, both foreign body-related and non-foreign body-related. Although biofilm infections can present in numerous ways, one common feature is involvement of the host response with significant impact on the course. A special characteristic is the synergy of the innate and the acquired immune responses for the induced pathology. Here, we review the impact of the host response for the course of biofilm infections, with special focus on cystic fibrosis, chronic wounds and infective endocarditis.

AB - Biofilm infections are one of the modern medical world's greatest challenges. Probably, all non-obligate intracellular bacteria and fungi can establish biofilms. In addition, there are numerous biofilm-related infections, both foreign body-related and non-foreign body-related. Although biofilm infections can present in numerous ways, one common feature is involvement of the host response with significant impact on the course. A special characteristic is the synergy of the innate and the acquired immune responses for the induced pathology. Here, we review the impact of the host response for the course of biofilm infections, with special focus on cystic fibrosis, chronic wounds and infective endocarditis.

KW - Biofilms

KW - Cystic Fibrosis

KW - Host-Pathogen Interactions

KW - Humans

KW - Immunity

KW - Pseudomonas Infections

KW - Pseudomonas aeruginosa

KW - Journal Article

KW - Review

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DO - 10.1111/apm.12674

M3 - Review

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VL - 125

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JO - APMIS. Supplementum

JF - APMIS. Supplementum

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ER -

Biofilms and host response - helpful or harmful

Abstract

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